Rattus norvegicus
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ABSTRACT:
PROVIDER: PRJNA90671 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:This is a study of femoral fracture healing in female rats 16 weeks old at fracture to compare intramedullary nailing, screw and plate fixation, and sham surgery. The sham surgery group received a surgical exposure of the femur, but no fracture, no plate, and no nail. Samples were collected at 1 day, 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after surgery. Each sample is a pool of RNA from three rats from the same surgery group at the same time point after fracture. The middle third of the femur was collected with the cortical bone, fracture callus, and marrow elements. Mid-diaphyseal, simple, transverse fractures were induced by a Gigli saw. The no fracture sample was a time 0 control collected on the day of surgery from intact rats.
2007-11-03 | E-GEOD-1685 | biostudies-arrayexpress
Project description:This is a study of femoral fracture healing in female rats 16 weeks old at fracture to compare intramedullary nailing, screw and plate fixation, and sham surgery. The sham surgery group received a surgical exposure of the femur, but no fracture, no plate, and no nail. Samples were collected at 1 day, 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after surgery. Each sample is a pool of RNA from three rats from the same surgery group at the same time point after fracture. The middle third of the femur was collected with the cortical bone, fracture callus, and marrow elements. Mid-diaphyseal, simple, transverse fractures were induced by a Gigli saw. The no fracture sample was a time 0 control collected on the day of surgery from intact rats. Keywords = rat Keywords = fracture Keywords = plate Keywords = nail Keywords = time Keywords = femur Keywords: time-course
2005-01-01 | GSE1685 | GEO
Project description:A study of rat femoral fracture healing in young (6 weeks old at fracture), adult (26 weeks old at fracture), and old (52 weeks old at fracture) rats. Samples were collected at time of surgery (intact controls) and at 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after fracture. Samples were the mid third of the femoral length including the external callus, cortical bone and marrow elements. Fracture was stabilized with an intramedullary rod prior to fracture with a Bonnarens and Einhorn device.
2007-11-03 | E-GEOD-1371 | biostudies-arrayexpress
Project description:mRNA expression in rat proximal femoral growthplate after mid-shaft fracture
| PRJNA92807 | ENA
Project description:Effect of Age on Fracture Healing in the Rat
| PRJNA85383 | ENA
Project description:mRNA gene expression was measured in intact female Sprague-Dawley rats at 6 (young), 26 (adult) and 52 (older) weeks of age at the time of fracture. Samples were collected at 0, 0.4, 1, 2, 4, and 6 weeks after fracture. RNA from two rats were pooled for each Affymetrix Rat U34A array. Mid-shaft, simple, transverse left femoral fractures were induced after retrograde intramedullary rod fixation with a Bonnarens and Einhorn device. Samples were collected from one third of the femoral length, centered on the fracture site, including the external callus, cortical bone, and marrow elements. Keywords = rat Keywords = fracture Keywords = age Keywords = time Keywords = femur Keywords: other
2004-01-10 | E-GEOD-594 | biostudies-arrayexpress
Project description:mRNA gene expression was measured in intact female Sprague-Dawley rats at 6 (young), 26 (adult) and 52 (older) weeks of age at the time of fracture. Samples were collected at 0, 0.4, 1, 2, 4, and 6 weeks after fracture. RNA from two rats were pooled for each Affymetrix Rat U34A array. Mid-shaft, simple, transverse left femoral fractures were induced after retrograde intramedullary rod fixation with a Bonnarens and Einhorn device. Samples were collected from one third of the femoral length, centered on the fracture site, including the external callus, cortical bone, and marrow elements. Keywords = rat Keywords = fracture Keywords = age Keywords = time Keywords = femur Keywords: other
2004-01-10 | GSE594 | GEO
Project description:After fracture, the femoral bone marrow microenvironment in mice initiates a series of reparative responses. The spatiotemporal coordinated regulation of gene expression not only determines the activation characteristics of hematopoietic and mesenchymal progenitors but also directly regulates the dynamic remodeling of various functional cell populations in the bone marrow microenvironment and the execution of bone repair functions. Historically, studies on the effects of intramedullary implant materials on the bone marrow microenvironment post-fracture have mostly relied on histological analysis of bulk tissues or functional assays of pre-selected isolated cell subsets. These approaches fail to accurately capture the heterogeneous transcriptional programs of individual cells, especially the dynamic transcriptional changes of cells in the bone marrow and on the implant surface after intramedullary nail placement. To systematically characterize the changes in the femoral bone marrow microenvironment after fracture and clarify the heterogeneity and dynamic transcriptional changes of cells in the bone marrow and on the implant surface following intramedullary nail placement, we employed single-cell mRNA sequencing (scRNA-seq) to profile the transcriptional landscapes of femoral bone marrow samples and implant-adherent cells from fracture mice implanted with intramedullary nails of different materials. This technique provides core data support for elucidating the molecular mechanisms underlying material-regulated cell differentiation trajectories and functional remodeling during fracture healing.
2026-03-26 | GSE313141 | GEO
Project description:Effect of Age on Fracture Healing in the Rat: Series 2
| PRJNA85379 | ENA
Project description:Effect of Age on Fracture Healing in the Rat: Series 1
| PRJNA85371 | ENA