Project description:To characterize the effect of microbiota on global gene expression in the distal small intestine during postnatal gut development we employed mouse models with experimental colonization by intestinal microbiota. Using microarray analysis to assess global gene expression in ileal mucosa at the critical stage of intestinal development /maturation associated with weaning, and asking how expression is affected by microbial colonization In the study presented here, preweaned and postweaned GF, SPF mouse small intestinal total RNAs were used. Also, 3-week-old gnotobiotic mouse as well as GF mouse small intestinal RNAs were used.

2013-03-02 | E-GEOD-44788 | biostudies-arrayexpress

E-MTAB-7604

Project description:RNA-sequencing of inflamed intestinal mucosa of inflammatory bowel disease patients

2025-01-23 | E-MTAB-7604 | ExpressionAtlas

Expression data from intestinal mucosa of Zucker rats

Project description:Obesity is a chronic, complex and multifactorial disease that has reached pandemia levels and is becoming a serious health problem. Intestinal microbiota is considered a main factor that affects body weight and fat mass, which points toward a critical role in the development of obesity. In this sense, probiotic bacteria might modulate the intestinal microbiota and the mucosal-associated lymphoid tissue. The aim of this study was to investigate the effects of L. paracasei, L. rhamnosus and B. breve feeding on the intestinal mucosa gene expression in a genetic animal model of obesity. We used microarrays to investigate the global gene expression on intestinal mucosa after the treatment with probiotic strains.

2016-12-25 | GSE73848 | GEO

E-GEOD-58086

Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [30_week_Liver]

2014-09-08 | E-GEOD-58086 | ExpressionAtlas

E-GEOD-58085

Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]

2014-09-08 | E-GEOD-58085 | ExpressionAtlas

Transcriptional Modulation of Genes by Gut Microbiota in Germfree and Conventional Mice

2013-03-02 | GSE44788 | GEO

Evaluation of different responses of the intestinal microbiota to a TNF-M-NM-1 mediated pro-inflammatory stimulus by the HTF-Microbi.Array

Project description:We developed a non-invasive ex vivo HT29 cell-based minimal model to fingerprint the mucosa-associated microbiota fraction in humans. HT29 cell-associated fractions were characterized by the universal phylogenetic array platform HTF-Microbi.Array, both in presence or in absence of a TNF-M-NM-1-mediated pro-inflammatory stimulus. A high taxonomical level fingerprint profiling of the mucosa-associated microbiota was performed on a group of 12 breast-fed infants and 6 adults (used as controls). Relative abundance of the bacterial species was assessed by using a so-called HTF-Microbi.Array, based on a ligation detection reaction (LDR) - Univerasal array (UA) assay, capable of correctly identify up to 31 intestinal bacterial groups, covering up to 95% of the human gut microbiota

2013-09-26 | E-GEOD-51177 | biostudies-arrayexpress

E-MEXP-1335

Project description:Transcription profiling by array of human intestinal mucosa after exposure to glutamine solution

2025-01-22 | E-MEXP-1335 | ExpressionAtlas