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ABSTRACT: humic acids facilitated better adaption of methanogens under micro-aeration

PROVIDER: PRJNA913197 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22811437_1.fastq.gz	Fastqsanger.gz
	SRR22811437_2.fastq.gz	Fastqsanger.gz
	SRR22811438_1.fastq.gz	Fastqsanger.gz
	SRR22811438_2.fastq.gz	Fastqsanger.gz
	SRR22811439_1.fastq.gz	Fastqsanger.gz

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EVALUATION OF THE EFFECTS OF HUMIC ACIDS ON MAIZE ROOT ARCHITECTURE BY LABEL-FREE PROTEOMICS ANALYSIS

Project description:Humic substances have been widely used as plant growth promoters to improve the yield of agricultural crops. Root soluble protein profiles of 11 days after planting, cultivated with and without humic acids (50 mg C/L), were analysed using the label-free quantitative proteomic approach. The effects on root architecture, such as induction of lateral root and biomass increase were accompanied by changes in the proteins.

2019-11-12 | PXD014407 | Pride

Analysis of the transcriptome of Lactococcus garvieae in presence or absence of Staphylococcus aureus and under a low or a high level of aeration by RNA sequencing

Project description:Lactococcus garvieae has a biopreservative potential against Staphylococcus aureus through its growth inhibition in dairy products. This inhibition involves the production of hydrogen peroxyde by L. garvieae under a high aeration level but little is known about the underlying metabolism. It has already been suggested that this inhibition involves another effector, still unidentified. In this experiment, we aimed to determine the changes in L. garvieae transcriptome depending on the aeration level or on the presence of S. aureus. The results led us to a better understanding of the relationship between the hydrogen peroxide metabolism and the inhibition of S. aureus and to suggest the involvement of other pathways wich may be related to the other and still unidentified effector.

2017-06-13 | GSE74030 | GEO

Project description:Effect of Humic acids on gut microbiota

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Project description:Fulvic acid more facilitated the soil electron transfer than humic acid

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Towards understanding the biological function of the unusual chaperonin GroEL1 of Mycobacterium tuberculosis

Project description:Expression data from wild type (H37Rv) and GroEL1(H37RvΔgroEL1::Hyg) mutant strains under a range of environmental stresses The 60 kDa heat shock proteins, also known as GroELs are components of the essential protein folding machinery of the cell, but are also dominant antigens in many infectious diseases. Although generally essential for cellular survival, in some organisms such as Mycobacterium tuberculosis, one or more paralogous GroELs are known to be dispensable. In M. tuberculosis, groEL2 is essential for cell survival, but the biological role of the non-essential GroEL1 is still elusive. To understand the relevance of GroEL1 in M. tuberculosis physiology, detailed transcriptomic analyses for the wild type H37Rv and groEL1 knockout (groEL1 KO) were performed under in vitro stress conditions: stationary phase, cold shock, low aeration, mild cold shock and low pH. Additionally, the survival of the groEL1 KO was assessed in macrophages at multiplicity of infection (MOI) of 1:1 and 1:5. We observed that survival under low aeration was significantly compromised in the groEL1 KO. Further, the gene expression analyses under low aeration showed change in expression of several key virulence factors like two component system PhoP/R and MprA/B, sigma factors sigG, M and H and adversely affected known hypoxia response regulators Rv0081, Rv0023 and DosR. Our work is therefore suggestive of an important role of GroEL1 for survival under low aeration by affecting the expression of genes known for hypoxia response.

2015-05-14 | GSE68856 | GEO

Transcriptional characterization of maize roots in response to nitrate (NO3-), Water-Extractable Humic Substances (WEHS) and NO3-+WEHS.

Project description:Soil humic substances are known to positively influence plant growth and nutrition. In particular, low-molecular fractions have been shown to increase NO3- uptake and PM H+-ATPase activity and alter expression of related genes. Changes in maize root transcriptome due to treatment with nitrate (NO3-), Water-Extractable Humic Substances (WEHS) and NO3-+WEHS were analyzed.

2018-07-30 | GSE103184 | GEO

Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating CYP1A1 expression

Project description:Humic substances are a mixture of natural organic macromolecular compounds, mainly fulvic acid (FA) (soluble in alkali, water, and acid) and humic acid (soluble in alkali but insoluble in water and acid). However, to the best of our knowledge, its antitumor effect remains indeterminate. Herein, we aimed to explore the effects and mechanisms of FA in ovarian cancer cells.

2025-04-17 | GSE253366 | GEO

Project description:effect of humic acids and chitosan on Alternaria solani

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Project description:The effectts of humic aicds on Bacteria and methanogens in anaerobic digesion

| PRJNA867492 | ENA

Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis

Project description:Tuberculosis caused by Mycobacterium tuberculosis (Mtb) infection remains a huge global public health problem. One striking characteristic of Mtb is its ability to adapt to hypoxia, and thus ensuing transition to dormant state for persistent infection, but how the hypoxia responses of Mtb is regulated remains largely unknown. Here, we performed a quantitative acetylome analysis to compare the acetylation profile of Mtb under aeration and hypoxia, and showed that 377 acetylation sites in 269 proteins of Mtb were significantly change under hypoxia. Especially, deacetylation of Dormancy Survival Regulator (DosR) at K182 promoted the hypoxia response of Mtb and enhanced transcription of DosR-targeted genes. Mechanistically, recombinant DosRK182R protein demonstrated enhanced DNA-binding activity in comparison with DosRK182Q protein. Moreover, Rv0998 was identified as an acetyltransferase that mediates the acetylation of DosR at K182. Deletion of Rv0998 also promoted the adaption of Mtb to hypoxia and transcription of DosR-targeted genes. Mice infected with Mtb strain containing acetylation-defective DosRK182R or lacking Rv0998 had much lower bacterial counts, and less severe histopathological impairments compared with those infected with the wild-type strain. Our findings suggest that hypoxia induces the deacetylation of DosR, which in turn increases its DNA binding ability to promote the transcription of target genes, allowing Mtbto transit to dormancy under hypoxia.

2018-10-22 | PXD008587 | Pride

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