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ABSTRACT: The dietary sweetener sucralose is a negative immunomodulator of T-cell- mediated responses

PROVIDER: PRJNA913879 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22811446_1.fastq.gz	Fastqsanger.gz
	SRR22811446_2.fastq.gz	Fastqsanger.gz
	SRR22811447_1.fastq.gz	Fastqsanger.gz
	SRR22811447_2.fastq.gz	Fastqsanger.gz
	SRR22811448_1.fastq.gz	Fastqsanger.gz

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The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

Project description:The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

| PRJNA911768 | ENA

The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

Project description:Sucralose is an artificial sweetener commonly used in food and drinks to increase food palatability and control total calorie content. While it is approved for human consumption by both the EFSA and the FDA, recent reports have questioned the safety of long-term consumption of s. in this study, we show that high doses of sucralose affect immune responses in different mouse models of autoimmunity, infection, and cancer. Similarly, sucralose impedes proper t cell proliferation and polarization in vitro. Mechanistically, sucralose dampens signals downstream the TCR resulting in decrease calcium flux upon TCR activation.

2023-03-14 | GSE220862 | GEO

In vitro exposure to sucralose ablates CD8 T cell responses

Project description:The composition of the gut microbiota is directly associated with response to checkpoint inhibitors in cancer. How diet impacts the gut microbiota and downstream immune response to cancer remains unclear. Here, we show that consumption of a common artificial sweetener, sucralose, supports microbial dysbiosis, restricts T cell metabolism and function, and limits immunotherapy response in cancer. Microbial dysbiosis is associated with a reduction in Arginine, and amino acid supplementation or fecal microbiome transfer completely restores T cell function and immunotherapy response. Thus, artificial sweetener consumption destabilizes the gut microbiota, resulting in compromised T cell function and ablated immunotherapy response in cancer.

2025-07-14 | GSE260936 | GEO

Sucralose Promote Food Intake Through NPY and A Neuronal Fasting Response

Project description:Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat.

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Zeaxanthin augments CD8+ effector T cell function by enhancing TCR stimulation

Project description:The detailed mechanisms underlying regulatory significance of dietary components in modulating anti-tumor immunity remain largely unknown. Here, we applied a co-culture screen approach using a blood nutrient compound library to identify zeaxanthin, a dietary carotenoid pigment found in many fruits and vegetables that is important for eye health, as an immunomodulator that enhances cytotoxicity of CD8+ T cells towards tumor cells. Oral zeaxanthin, but not lutein, a carotenoid with similar structure, enhances anti-tumor immunity in vivo. Integrated multi-omics mechanistic studies reveal that zeaxanthin directly promotes T-cell receptor (TCR) stimulation on CD8+ T cell surface, leading to improved intracellular TCR signaling for effector T cell function. Hence, zeaxanthin treatment augments effectiveness of immune checkpoint inhibitor in vivo and human TCR-engineered CD8+ T cells to induce cell death in co-cultured tumor cells. Our findings uncover a previously unknown immunoregulatory function of zeaxanthin, which has translational potential as a dietary element in immunotherapy.

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In vitro exposure to sucralose ablates CD8 T cell responses

Project description:In vitro exposure to sucralose ablates CD8 T cell responses

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In vitro exposure to sucralose ablates CD8 T cell responses [scRNA-seq]

Project description:In vitro exposure to sucralose ablates CD8 T cell responses [scRNA-seq]

| PRJNA1299318 | ENA

Zeaxanthin augments CD8+ effector T cell function by enhancing TCR stimulation

2025-08-22 | GSE282703 | GEO

β2 adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses

Project description:β2 adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses

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Immune Checkpoints in Colorectal Cancer

Project description:Colorectal cancer (CRC) ranked the first in cancer incidence in Hong Kong and it is frequently lethal with heterogeneous drug responses and survival outcomes. Immune-based approaches targeting to enhance tumor-specific responses have been actively under investigation as therapeutic strategies. Currently, PD1 and PD-L1 blockade has shown promising results in clinical trials especially in colorectal cancer patients with microsatellite instability. This study aims to examine the role of PD-L1/PD1 in immune cell-mediated cytotoxicity in colorectal cancer patients.

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