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The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

ABSTRACT: The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

PROVIDER: PRJNA911768 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22711000.fastq.gz	Fastqsanger.gz
	SRR22711001.fastq.gz	Fastqsanger.gz
	SRR22711002.fastq.gz	Fastqsanger.gz
	SRR22711003.fastq.gz	Fastqsanger.gz
	SRR22711004.fastq.gz	Fastqsanger.gz

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The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

Project description:Sucralose is an artificial sweetener commonly used in food and drinks to increase food palatability and control total calorie content. While it is approved for human consumption by both the EFSA and the FDA, recent reports have questioned the safety of long-term consumption of s. in this study, we show that high doses of sucralose affect immune responses in different mouse models of autoimmunity, infection, and cancer. Similarly, sucralose impedes proper t cell proliferation and polarization in vitro. Mechanistically, sucralose dampens signals downstream the TCR resulting in decrease calcium flux upon TCR activation.

2023-03-14 | GSE220862 | GEO

In vitro exposure to sucralose ablates CD8 T cell responses

Project description:The composition of the gut microbiota is directly associated with response to checkpoint inhibitors in cancer. How diet impacts the gut microbiota and downstream immune response to cancer remains unclear. Here, we show that consumption of a common artificial sweetener, sucralose, supports microbial dysbiosis, restricts T cell metabolism and function, and limits immunotherapy response in cancer. Microbial dysbiosis is associated with a reduction in Arginine, and amino acid supplementation or fecal microbiome transfer completely restores T cell function and immunotherapy response. Thus, artificial sweetener consumption destabilizes the gut microbiota, resulting in compromised T cell function and ablated immunotherapy response in cancer.

2025-07-14 | GSE260936 | GEO

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.

Project description:Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years1. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners2-5. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8+ T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders.

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Sucralose Promote Food Intake Through NPY and A Neuronal Fasting Response

Project description:Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat.

2016-07-10 | GSE73179 | GEO

Project description:The dietary sweetener sucralose is a negative immunomodulator of T-cell- mediated responses

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sucralose administration in mice

Project description:sucralose administration in mice Raw sequence reads

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In vitro exposure to sucralose ablates CD8 T cell responses

Project description:In vitro exposure to sucralose ablates CD8 T cell responses

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Sucralose-degrading enriched consortia

Project description:Sucralose biodegradation and the enriched degrading-consortia revealed by combining Illumina and Nanopore sequencing

| PRJNA728822 | ENA

The tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 2)

Project description:Epithelial tissues are highly organized structures that rely on cell polarity pathways driven by membrane receptors and scaffolding proteins. SCRIBBLE is a cytoplasmic scaffold present at cell-cell junctions in polarized cells that contains LRR and PDZ domains. The current interactome of SCRIB and LRRC1 consists of 67 and 30 protein interaction partners respectively with only 9 (10%) common partners (BioGRID, version 3.5). Our study identified a protein complex associated to SCRIB stabilized by the inhibition of the proteasome and further characterize SCRIB act as negative modulator of the Wnt/β-catenin signaling.

2019-09-25 | PXD013636 | Pride

In vitro exposure to sucralose ablates CD8 T cell responses [scRNA-seq]

Project description:In vitro exposure to sucralose ablates CD8 T cell responses [scRNA-seq]

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