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ABSTRACT: Mouse lung transcriptome following sleep deprivation

PROVIDER: PRJNA914246 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22827464_1.fastq.gz	Fastqsanger.gz
	SRR22827464_2.fastq.gz	Fastqsanger.gz
	SRR22827465_1.fastq.gz	Fastqsanger.gz
	SRR22827465_2.fastq.gz	Fastqsanger.gz
	SRR22827466_1.fastq.gz	Fastqsanger.gz

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Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation

Project description:Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, whether acute sleep deprivation has impact on the circadian rhythms is not clear. Here, we show that in mouse lung, a 10-hour acute sleep deprivation can alter the circadian expression of approximally 3,000 genes. We found that circadian rhythm disappears in genes related to metabolism and signaling pathways regulating protein phosphorylation after acute sleep deprivation, while the core circadian regulators do not change much in rhythmicity. Importantly, the strong positive correlation between mean expression and amplitude (E-A correlation) of cycling genes has been validated in both control and sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression. Thus, we reveal that acute sleep deprivation leads to a profound change in the circadian gene transcription that influences the biological functions in lung.

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Project description:Molecular profiles in sleep and sleep deprivation in peripheral tissues using microarrays Time point study. Mice were sacrificed by cervical dislocaton following 3, 6, 9, and 12 h of total sleep deprivation (n = 8 or 9 at each time point). Deprivation was initiated at lights-on and performed through gentle handling.

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