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RNA array data of abdominal adipose tissue post duodenal-jejunal bypass (DJB)

ABSTRACT: RNA array data of abdominal adipose tissue post duodenal-jejunal bypass (DJB)

PROVIDER: PRJNA916219 | ENA |

REPOSITORIES: ENA

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RNA array data of abdominal adipose tissue post duodenal-jejunal bypass (DJB)

Project description:To analyze the mRNA, lncRNA, and circRNA expression profile in abdominal adipose tissues post DJB surgery, high-fat diet induced typical diabetic mice were underformed sham surgery or DJB surgery. Two weeks post the surgery, mice were enthanized and the abdominal adipose tissues were collected for RNA array analysis. To analyze the ceRNA networks regulated by DJB surgery

2023-12-22 | GSE221792 | GEO

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Alteration of ileal lncRNAs after bariatric surgery is associated with regulation of lipid and amino acid metabolism

Project description:Metabolic and bariatric surgery (MBS) can generate a drastic shift of coding and non-coding RNAs expression pattern, which triggers organ function remodeling and may induce type 2 diabetes (T2D) remission. Our previous studies demonstrated that the altered expression profiles of duodenal and jejunal long noncoding RNAs (lncRNAs) after the duodenal-jejunal bypass (DJB), an investigational procedure and research tool of MBS, can improve glycemic control by modulating entero-pancreatic axis and gut-brain axis, respectively. As an indiscerptible part of intestine, the ileal lncRNAs expression signatures after DJB and the critical pathways associated with postoperative correction of impaired metabolism need to be investigated

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Expression data from human abdominal, subcutaneous adipose tissue

Project description:FCHL is a common, complex genetic lipid disorder with a largely unknown aetiology. Altered adipose tissue metabolism has been implicated as contributing to FCHL. We used microarrays to investigate the mRNA profiles of FCHL patients with CHD and non-FCHL patients with CHD in comparison with non-FCHL, non-CHD patients to define a core set of genes that were differentially expressed in FCHL and to provide a reasonable launch-pad for examining the direct contribution of one of this gene set to the development of adipose tissue. Adipose tissue was obtained from the same anatomical site - the subcutaneous, upper abdominal region - of white British males, either at coronary artery bypass surgery (designated as: FCHL-CHD (13 individuals, subdivided on TG response to statins into Group 1 (n=4), Group 2 (n=7) and unclassified (n=2)) and non-FCHL-CHD patients (6 individuals)), or at heart valve replacement: non-FCHL, non-CHD subjects (5 individuals; controls).

2013-10-29 | E-GEOD-51625 | biostudies-arrayexpress

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Duodenal-Jejunal Bypass Restores Sweet Taste Receptor-Mediated Glucose Sensing and Absorption in Diabetic Rats.

Project description: Not available

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Conversion of Roux-en-Y gastric bypass to single anastomosis duodenal ileal bypass with sleeve gastrectomy with gastrogastric jejunal bridge

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jejunal contents

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miRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss

Project description:Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this would provide insights into their role in obesity-induced metabolic dysregulation. Methods: miRNA-profiling (Affymetrix_Gene-Chip_miRNA2.0_Arrays) of omental and subcutaneous adipose (n=15 females) before, and after, gastric bypass surgery. Results: One omental, and thirteen subcutaneous adipose miRNAs were significantly, differentially expressed after gastric bypass, including down-regulation of miR-223-3p and its antisense relative, miR-223-5p, in both adipose tissues. mRNA levels of miR-223-3p targets NLRP3 and GLUT4 were increased and decreased respectively following gastric bypass in both adipose tissues. Significantly more NLRP3 protein was observed in omental adipose after gastric bypass (P=0.02). Significant hypomethlyation of NLRP3 and hypermethylation of miR-223 was observed in both adipose tissues after gastric bypass. In subcutaneous adipose significant correlations were observed between both miR-223-3p and miR-223-5p and glucose, and between NLRP3 mRNA and protein levels and blood lipids. Conclusions: This is the first report detailing genome-wide miRNA-profiling of omental adipose before and after gastric bypass, and further highlights a link between miR-223-3p and the NLRP3 inflammasome in obesity.

2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress

Visceral adipose tissue contributes to improved insulin resistance after DJB via growth hormone-adiponectin axis

Project description:To explore the potential mechanism of duodeno-jejunal bypass (DJB) in improving insulin resistance in diabetic rats, we suggest that adipose tissue is involved in the regulation. To investigate genetic changes in adipose tissue after duodeno-jejunal bypass, we performed RNA-seq analysis to establish the relationship between growth hormone, adiponectin, and insulin sensitivity by measuring changes in growth hormone pathways, including downstream JAK2 and MAPK pathways, and investigated non-PPAR signaling pathways. This study deepens our understanding of the complex mechanism by which DJB affects insulin resistance. This meticulous exploration fills an important gap in the literature and may pave the way for more targeted and effective diabetes management interventions.

2023-09-22 | GSE243812 | GEO

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