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Streptococcus pneumoniae endopeptidase O (PepO) induces trained immunity to defend the host against numerous pathogen infections

ABSTRACT: Streptococcus pneumoniae endopeptidase O (PepO) induces trained immunity to defend the host against numerous pathogen infections

PROVIDER: PRJNA918587 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22984665_1.fastq.gz	Fastqsanger.gz
	SRR22984665_2.fastq.gz	Fastqsanger.gz
	SRR22984666_1.fastq.gz	Fastqsanger.gz
	SRR22984666_2.fastq.gz	Fastqsanger.gz
	SRR22984667_1.fastq.gz	Fastqsanger.gz

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Streptococcus pneumoniae endopeptidase O (PepO) induces trained immunity to defend the host against numerous pathogen infections

Project description:Antibiotic resistance and the pandemic of infectious diseases pose major hazards to human health. As a novel anti-infection strategy, trained immunity has a promising future. Recombinant Streptococcus pneumoniae Endopeptidase O (rPepO) is a novel trained immunity inducer that is a highly effective broad-spectrum anti-infective molecule. Here, we demonstrate that rPepO training induces a protective effect by improving the function of several immune cells. rPepO trains macrophages in the periphery to improve their immunological response. In addition, macrophage-derived complement C3 stimulates B lymphocytes to bolster the host's initial line of defense. While trained-macrophage-derived G-CSF changes the host's hematopoiesis and promotes central trained immunity. The "trained" label is found on freshly differentiated mononuclear macrophages, which also possess significantly enhanced anti-infective properties. Consequently, our research reveals that rPepO can induce peripheral and central trained immunity and possesses broad-spectrum and durable antimicrobial characteristics.

2023-12-31 | GSE222201 | GEO

Comparison of gene expression in the GAS M1T1 strain 5448, wild-type vs pepO mutant

Project description:Manuscript title: The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. The study investigates the effect of pepO mutation on global gene expression in GAS M1T1 strain 5448.

2018-01-05 | GSE108748 | GEO

Cucurbita pepo subsp. pepo

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Cucurbita pepo subsp. pepo

Project description:Cucurbita pepo subsp. pepo RNA sequencing and assembly

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Cucurbita pepo subsp. pepo cultivar:C39

Project description:Cucurbita pepo subsp. pepo cultivar:C39 Genome sequencing

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Gene expression in squash (Cucurbita pepo) nectaries

Project description:Nectaries are the glands responsible for nectar secretion. To understand the genetic programming underlying nectar production, male and female squash(Cucurbita pepo) floral nectaries at four different time points (pre-secretion #1, pre-secretion #2, secretory, and post-secretory) in biological triplicate were collected, with RNA being isolated and subjected to Illumina RNA-seq analysis.

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Cucurbita pepo subsp. pepo cultivar:San Pasquale

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