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Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

ABSTRACT: Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

PROVIDER: PRJNA923023 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23054881_1.fastq.gz	Fastqsanger.gz
	SRR23054881_2.fastq.gz	Fastqsanger.gz
	SRR23054882_1.fastq.gz	Fastqsanger.gz
	SRR23054882_2.fastq.gz	Fastqsanger.gz
	SRR23054883_1.fastq.gz	Fastqsanger.gz

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Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild Orientia tsutsugamushi Infection

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Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

Project description:We performed RNAseq on total RNA extracted from splenic B cells isolated from mice infected with Orientia tsutsugamushi to investigate the dynamic transcriptomic signature of these cells throughout infection. We then performed differential expression analysis, meta-analysis, and gene set enrichment anaylsis using data obtained by RNA-seq of mock infected (D0) and O. tsutsugamushi-infected mice (D4 and D8).

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