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Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [NanoString]

ABSTRACT: Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [NanoString]

PROVIDER: PRJNA923659 | ENA |

REPOSITORIES: ENA

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Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [NanoString]

Project description:Hepatocellular carcinoma is the most frequent species of liver cancer and the identification of new prognostic factors opens new perspectives for therapy. Circulating and cellular onco-miRNAs are non coding RNAs which can control oncogenesis-related gene expression through post-transcriptional mechanisms and are considered novel prognostic and predictive factors in cancer biology. The apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) contributes in the quality control and processing of specific onco-miRNAs, and is a negative prognostic factor in many tumors. The present work aims: a) to define APE1 prognostic value in HCC; b) to identify miRNAs regulated by APE1 and their relative target genes, and c) to study their prognostic value.

2023-09-21 | GSE222851 | GEO

Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma

Project description:Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma

| PRJNA923654 | ENA

Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [RNA-Seq]

Project description:Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [RNA-Seq]

| PRJNA923660 | ENA

Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma [RNA-Seq]

2023-09-21 | GSE222852 | GEO

Clinical significance of apurinic/apyrimidinic endodeoxyribonuclease 1 and microRNAs axis in hepatocellular carcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-21 | GSE222853 | GEO

APE1 (apurinic/apyrimidinic endonuclease 1): newly identified post-translational modifications (PTMs)

Project description:APE1 (apurinic/apyrimidinic endonuclease 1) is a multifunctional protein essential for both DNA base excision repair and redox signaling. However, its post-translational modifications (PTMs), which are key to modulating its cellular functions, remain largely uncharacterized due to their dynamic and labile nature. In this study, we developed a novel biotin-regulated avidin-based magnetic nanoparticle platform (bMIPAPE1) that selectively captures active APE1 from living cells under native conditions. This approach preserves labile PTMs and enables downstream mass spectrometry-based proteomic analysis. Using this tool, we identified 27 previously unreported PTMs at 18 distinct residues, including modifications with critical functional implications, such as phosphorylation at Y269 and dual acetylation/palmitoylation at K228. Furthermore, we uncovered PTMs associated with subcellular localization, including modifications at K203, C208, and K63 that correlated with APE1 nuclear export. Beyond enrichment and profiling, bMIPAPE1 also inhibits the enzymatic functions of APE1 in cells, offering potential therapeutic relevance. This project showcases an innovative method for real-time PTM profiling of endogenous proteins in complex cellular environments, with implications for cancer biology and targeted drug discovery.

2026-03-17 | PXD067266 | Pride

An APE1 Inhibitor Reveals Critical Roles of APE1 Redox Function in Pathogenesis of Chronic Rhinosinusitis and Novel Therapeutics

Project description:We demonstrated that the Apurinic/apyrimidinic endonuclease 1 (APE1) redox inhibitor, C10, effectively blocked Type 2 inflammation and improved chronic rhinosinusitis (CRS) pathology in a mouse model.

2025-07-01 | GSE285228 | GEO

An APE1 Inhibitor Reveals Critical Roles of APE1 Redox Function in Pathogenesis of Chronic Rhinosinusitis and Novel Therapeutics

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The therapeutic potential and significance of the PELP1 signaling pathway in hepatocellular carcinoma

Project description:We examined the significance and therapeutic potential of targeting PELP1 in Hepatocellular carcinoma. Total RNA were isolated from HEP3B-control Sh, and HEP3B-PELP1-Sh cells using RNeasy mini kit, and total RNA was isolated for RNA-seq analysis. Our results demonstrated that PELP1 knockdown regulates pathways related to inflammation and interferon signaling and downregulates several pathways including MYC and E2F.

2024-10-16 | GSE254860 | GEO

APE1 controls DICER expression through functional regulation of miRNA33a: a novel hypothesis for NSCLC cancer progression [RNA-Seq]

Project description:The overexpression of the DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) is an important cause of poor outcome and its expression is able to predict the progression-free and overall survival in patients receiving platinum-containing chemotherapy. Recently, we have demonstrated APE1 involvement in miRNA biogenesis related to cancer progression.

2022-08-03 | GSE166664 | GEO

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