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Differential gene expression in the grf10Δ mutant of Candida albicans in high copper containing growth medium

ABSTRACT: Differential gene expression in the grf10Δ mutant of Candida albicans in high copper containing growth medium

PROVIDER: PRJNA925238 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23116604_1.fastq.gz	Fastqsanger.gz
	SRR23116604_2.fastq.gz	Fastqsanger.gz
	SRR23116605_1.fastq.gz	Fastqsanger.gz
	SRR23116605_2.fastq.gz	Fastqsanger.gz
	SRR23116606_1.fastq.gz	Fastqsanger.gz

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Differential gene expression in the grf10Δ mutant of Candida albicans in high copper containing growth medium

Project description:To identify genes in that are misregulated in the grf10Δ mutant of Candida albicans in response to growth in high copper, we compared expression patterns of the grf10-null mutant relative to the isogenic WT in YPD medium supplemented with and without 12 mM CuSO4.

2023-03-20 | GSE223217 | GEO

Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast Candida albicans

Project description:Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans. However, beyond the copper transporter Ctr1, little is known regarding other genes or biological process that are affected by copper. To gain insight into the cellular processes that are modulated by copper abundance in C. albicans, we monitored the global gene expression dynamic under both copper depletion and excess using RNA-seq.

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Project description:The fungal pathogen Candida albicans produces dark-pigmented melanin when grown in a basal medium containing 1 mM l-DOPA as melanin substrate. In the widely used C. albicans strain SC5314, melanin appeared after 3-4 days of incubation in l-DOPA medium. The experiment was designed to reveal cadidate genes associated with melanin biosynthesis by expression profiling at different times of growth with and without L-DOPA added to the medium. Expression profiling of C. albicans revealed very few genes significantly up- or down-regulated by growth in l-DOPA.

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Project description:Transcriptional profiling of Candida albicans after 3 h phagocytosis by vehicle DMSO-treated macrophages (intact, expanding phagosomes) or calcium chelator BAPTA-AM-treated macrophages (inhibits lysosomal repair of expanding phagosomes, leading to phagosome rupture) to determine the effect of preventing phagosome expansion on C. albicans gene expression after phagocytosis by macrophages. Cultivation of Candida only for 3 h in DMEM-FBS cell culture medium or YPD complex medium as non-phagocytosis control conditions.

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Manganese-modulated proteome and phospho-proteome of the opportunistic yeast Candida albicans

Project description:The ability of the opportunistic yeast Candida albicans to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environment, is an important determinant of its fitness. Although significant focus has been given to mechanisms of iron and copper acquisition and their roles in C. albicans fitness, little is known about how this yeast maintain and control Mn homeostasis. Here, we presented a comparative proteomic and phospho-proteomic analysis in C. albicans cells experiencing Mn starvation. Both proteome and phosphoproteome of the C. albicans reference strain SC5314 growing in Mn-depleted medium were compared to those of cells thriving in Mn-repleted medium. Samples were collected in four biological replicates at two time-points (5 and 90 min). LC–MS/MS identified approximately 1500 differentially abundant proteins and over 140 phosphorylated proteins.

2025-06-12 | PXD064206 | Pride

Candida albicans Microarray studies: CAP2 (Wild type) vs. cap2D (Homozygous null mutant)

Project description:Transcriptome profiling to identify Cap2/Hap43 regulons in the human fungal pathogen Candida albicans: Wild type vs. cap2D grown in iron-depleted medium

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Absolute expression level of Candida albicans genes

Project description:Total RNA versus genomic DNA hybridization on custom arrays designed for all Candida albicans genes Total RNA was collected in mid-log phase from Candida albicans cells grown in rich medium (abbreviated CM, in house recipe). RNA was then converted to cDNA, Cy3-labeled and hybridized competitively against Cy5 labeled genomic DNA from Candida albicans

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Project description:Candida albicans Sequencing

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Time course gene expression profile of YPD medium grown Candida albicans mss11 mutant

Project description:Candida albicans is an important fungal pathogen in humans. Several virulence factors of C. albicans have been reported, including a morphological transition from yeast to filamentous forms (hyphae and pseudohyphae). Mss11 is a transcriptional activator required for hyphal formation. To reveal the potential target genes of Mss11, DNA microarray analysis was performed to compare wild type and mss11-deleted mutant.

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