Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An in vivo massively parallel platform for deciphering tissue-specific regulatory function [RNA]

ABSTRACT: An in vivo massively parallel platform for deciphering tissue-specific regulatory function [RNA]

PROVIDER: PRJNA925554 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23136800_1.fastq.gz	Fastqsanger.gz
	SRR23136800_2.fastq.gz	Fastqsanger.gz
	SRR23136801_1.fastq.gz	Fastqsanger.gz
	SRR23136801_2.fastq.gz	Fastqsanger.gz
	SRR23136802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 100

Similar Datasets

An in vivo massively parallel platform for deciphering tissue-specific regulatory function

Project description:An in vivo massively parallel platform for deciphering tissue-specific regulatory function

| PRJNA925558 | ENA

An in vivo massively parallel platform for deciphering tissue-specific regulatory function [DNA]

Project description:An in vivo massively parallel platform for deciphering tissue-specific regulatory function [DNA]

| PRJNA925534 | ENA

An in vivo massively parallel platform for deciphering tissue-specific regulatory function [RNA]

Project description:Massively parallel reporter assays (MPRAs) have the potential to link differences in genome sequence, including genetic variants, to tissue-specific regulatory function. Whole-animal MPRA (WhAMPRA), where systemic intravenous AAV effectively transduces the plasmid MPRA library to mouse tissues. This technology simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues

2025-03-24 | GSE223306 | GEO

An in vivo massively parallel platform for deciphering tissue-specific regulatory function [DNA]

2025-03-24 | GSE223293 | GEO

A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

Project description:A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

| PRJNA1221949 | ENA

Massively Parallel Dissection of RNA in RNA-protein Interactions in vivo

Project description:Massively Parallel Dissection of RNA in RNA-protein Interactions in vivo

| PRJNA914866 | ENA

Mapping of copy-number alterations with massively parallel sequencing

Project description:This SuperSeries is composed of the following subset Series: GSE12019: Fine-scale mapping of copy-number alterations with massively parallel sequencing GSE13372: High-resolution mapping of copy-number alterations with massively parallel sequencing Refer to individual Series

2008-11-13 | E-GEOD-13373 | biostudies-arrayexpress

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

Project description:Leveraging AAV's versatile tropism and labeling capacity, we expanded the scale of in vivo CRISPR screen with single-cell transcriptomic phenotyping across embryonic to adult brains and peripheral nervous systems. Through extensive tests of 86 AAV serotypes, combined with transposon systems, we substantially amplified labeling and accelerated in vivo gene delivery from weeks to days. Our proof-of-principle in utero screen identified the pleiotropic effects of Foxg1, highlighting its tight regulation of distinct networks essential for cell fate specification of Layer 6 corticothalamic neurons. Notably, our platform can label >6% of cerebral cells, surpassing the current state-of-the-art efficacy at <0.1% by lentivirus, to achieve analysis of over 30,000 cells in one experiment and enable massively parallel in vivo Perturb-seq. Compatible with various phenotypic measurements (single-cell or spatial multi-omics), it presents a flexible approach to interrogate gene function across cell types in vivo, translating gene variants to their causal function.

2023-12-05 | GSE249416 | GEO

An in vivo massively parallel platform for deciphering tissue-specific regulatory function

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-24 | GSE223307 | GEO

Massively parallel engineering of persistent CAR-Ts

Project description:Massively parallel engineering of persistent CAR-Ts

| PRJNA906963 | ENA