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Gene expression profile at single cell level of Wilms tumors and normal kidney tissues from an infant with Denys-Drash syndrom

ABSTRACT: Gene expression profile at single cell level of Wilms tumors and normal kidney tissues from an infant with Denys-Drash syndrom

PROVIDER: PRJNA925887 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23163436_1.fastq.gz	Fastqsanger.gz
	SRR23163436_2.fastq.gz	Fastqsanger.gz
	SRR23163437_1.fastq.gz	Fastqsanger.gz
	SRR23163437_2.fastq.gz	Fastqsanger.gz
	SRR23163438_1.fastq.gz	Fastqsanger.gz

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Gene expression profile at single cell level of Wilms tumors and normal kidney tissues from an infant with Denys-Drash syndrom

Project description:Denys-Drash syndrom is a rare disease. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of kidney tissue cells in an infant with Denys-Drash syndrom.

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Project description:Purpose: The 10x Genomics Visium platform allows us to define the spatial topography of gene expression and provides detailed molecular maps that overcome limitations associated with sn/scRNA-seq and microscopy-based spatial transcriptomics methods. The goals of this study are to compare and identify unique transcriptome profiling (RNA-seq) signature between unfavorable and favorable Wilms Tumors and against human fetal kidney. Methods: Human fetal kidney and Wilms tumor spatial topography of gene expression were generated using the 10X Visium platform Results: Using an optimized data analysis workflow, we mapped the reads to the hg38 genome build and grouped the spots into 9 clusters based on gene expression profiles. Conclusion: Our study represents the first implement of Visium technology in human fetal kidney and Wilms Tumor tissue, providing a number of important functional insights about the spatial and molecular definitions of cell populations across human fetal kidney and different subtypes of Wilms Tumor through analyzing gene expression within the intact spatial organization of the human samples.

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Project description:The global gene expression pattern of Wilms tumors in comparison with clear cell sarcoma of the kidney (CCSK) and non-neoplastic fetal and adult kidneys.

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Project description:The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.

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Project description:The aim of the study was to identify key transcriptional regulators that might be responsible for the increased resistance to chemotherapy of blastemal Wilms tumors.

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2015-04-21 | GSE56955 | GEO

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