Project description:The serum of hibernating bears has been shown to exhibit cytoprotective, anticatabolic effects when applied to human or mouse skeletal muscle cells. It is also able to reduce mitochondrial respiration in cells obtained from bear adipose tissue. Its action notably might involve reprogramming of transcriptional profiles, as shown in brown bear adipocytes and more recently in human muscle cells. However, the effects of bear serum on human cells has not been evaluated yet at the proteome level. The main objective of this study was to fill this gap by comparing the effects of hibernating bear serum with those of non-hibernating bear serum and foetal bovine serum on human fibroblasts.
Project description:Shotgun genome sequencing of 4 ancient cave bears (Ursus spelaeus complex), 1 ancient brown bear and 3 modern brown bears (Ursus arctos)
| PRJEB27491 | ENA
Project description:Brown bear tissue full length transcriptome sequencing
| PRJNA727613 | ENA
Project description:Brown bear phylogeography across the Eurasian mainland