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DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

ABSTRACT: DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

PROVIDER: PRJNA930718 | ENA |

REPOSITORIES: ENA

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DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Heterochronic parabiosis and recovery from this procedure is one such example.

2023-04-21 | GSE224361 | GEO

DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

Project description:DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

| PRJNA931268 | ENA

DNA methylation and gene expression changes in mice induced by parabiosis and recovery

Project description:DNA methylation and gene expression changes in mice induced by parabiosis and recovery

| PRJNA931263 | ENA

DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age is perturbed. Heterochronic parabiosis and recovery from this procedure is one such example.

2023-04-21 | GSE224442 | GEO

DNA methylation changes in mice induced by mock parabiosis

Project description:DNA methylation changes in mice induced by mock parabiosis

| PRJNA991712 | ENA

DNA methylation changes in mice induced by mock parabiosis

2023-07-06 | GSE236617 | GEO

Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age is perturbed. Heterochronic parabiosis and recovery from this procedure is one such example.

2023-04-21 | GSE224378 | GEO

Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

Project description:Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

| PRJNA930740 | ENA

DNA methylation and gene expression changes in mice induced by parabiosis and recovery

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-21 | GSE224447 | GEO

UVB irradiation does not directly induce detectable changes of DNA methylation in human keratinocytes

Project description:Unprotected exposure to UVB radiation from the sun and the resulting DNA damage are thought to be responsible for physiological changes in the skin and for a variety of skin cancers, including basal cell and squamous cell carcinoma and malignant melanoma. Although the mutagenic effects of UVB have been well documented and studied mechanistically, there is only limited information as to whether UV light may also be responsible for inducing epigenetic changes in the genome of exposed cells. DNA methylation is a stable epigenetic modification involved in gene control. To study the effects of UVB radiation on DNA methylation, we repeatedly exposed normal human keratinocytes to a UVB light source. After a recovery period, we analyzed global DNA methylation patterns in the irradiated and control cells using the methylated-CpG island recovery assay (MIRA) method in combination with high-resolution microarrays. Bioinformatics analysis revealed only a limited number of possible differences between UVB-exposed and control cells. However, these minor apparent changes could not be independently confirmed by bisulfite sequencing-based approaches. This study reveals that UVB irradiation of keratinocytes has no recognizable global effect on DNA methylation patterns and suggests that changes in DNA methylation, as observed in skin cancers, are not immediate consequences of human exposure to solar UVB irradiation. DNA methylation analysis of control and UVB irradiated keratinocytes. The MIRA assay was used for enrichment of methylated DNA. NimbleGen CpG island plus promoter arrats were used.

2013-01-30 | E-GEOD-42943 | biostudies-arrayexpress

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