Saccharomyces cerevisiae
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA93421 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Expression profile of hsp31∆, hsp32∆, hsp33∆ during diauxic shift
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Project description:Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ixr1 null, grown in aerobic, hypoxic conditions and after a hypoxic shift
2012-09-13 | GSE30046 | GEO
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Project description:Samples GSM206658-GSM206693: Acquired Stress resistance in S. cerevisiae: NaCl primary and H2O2 secondary Transcriptional timecourses of yeast cells exposed to 0.7M NaCl alone, 0.5mM H2O2 alone, or 0.5mM H2O2 following 0.7M NaCl, all compared to an unstressed sample. Repeated using msn2∆ strain. Samples GSM291156-GSM291196: Transcriptional response to stress in strains lacking MSN2 and/or MSN4 Transcriptional timecourses of yeast cells (WT, msn2∆, msn4∆, or msn2∆msn4∆) exposed to 0.7M NaCl for 45 minutes or 30-37˚C Heat Shift for 15 min compared to an unstressed sample of the same strain. Keywords: Stress Response
2008-09-05 | GSE8335 | GEO
Project description:A shift from pleiotropic to modular adaptation revealed by a high-resolution two-step adaptive walk
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Project description:Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ixr1 null, grown in aerobic, hypoxic conditions and after a hypoxic shift Two biological replicates in two technical replicates for each growth condition
2012-09-13 | E-GEOD-30046 | biostudies-arrayexpress
Project description:<p>Despite extensive research on Saccharomyces cerevisiae functional genomics, approximately 880 out of ~6,000 open reading frames (ORFs) remain uncharacterised. In this study we propose a method for characterising genes with limited prior functional knowledge using an automated laboratory platform, in conjunction with several hypothesis instantiation methods. We demonstrate this method by investigating YGR067C, an uncharacterised ORF hypothesised to regulate respiration during the diauxic shift. Predictions of the first-order effects of deletion were obtained by curating a list of pathways relevant to the hypothesis. Higher-order effects were predicted using simulation models based on the GEM Yeast9. The predictions were tested using empirical data from biological experiments performed in the Robot Scientist Eve, which generated OD560, transcriptomics, and metabolomics data. </p><p>We observed that YGR067C deletion led to downregulation of transcripts in some ethanol consuming respiratory pathways during the glucose phase. During the ethanol phase we observed that NAD+, NADP+ and NADH accumulated, and several amino acid biosynthesis pathways were enriched for the ygr067c∆ strain, suggesting longer term consequences of YGR067C mediated regulation. Based on these observations we propose that the role of YGR067C during the diauxic shift is to regulate genes related to ethanol consumption and respiration in the glucose phase.</p>
2025-12-03 | MTBLS12663 | MetaboLights