Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Superficieibacter sp. HKU1 isolate:hospitalised patient

ABSTRACT: Superficieibacter sp. HKU1 isolate:hospitalised patient Genome sequencing

PROVIDER: PRJNA940906 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Staphylococcus sp. HKU1

Project description:Staphylococcus sp. HKU1 Genome sequencing

| PRJNA1004220 | ENA

HKU1 isolate in primary cells

Project description:HKU1 isolate in primary cells

| PRJEB64017 | ENA

HKU1 internal protein ameliorate infection in mice

Project description:Coronaviruses express a repertoire of accessory proteins for evading host immune responses. Among these accessory proteins, a small internal (I) protein is expressed by members of the genus Betacoronavirus. Previous studies reported that the I proteins of SARS-CoV, MERS-CoV and SARS-CoV-2 inhibit type I interferon (IFN-I) expression through distinct mechanisms and play different roles in pathogenesis. In addition, human coronaviruses HKU1 and OC43 are betacroaonvairuses that predominantly cause common cold and encode the I protein as one of their accessory proteins; the I proteins of hCoV-HKU1 and hCoV-OC43 have not been previously characterized. However, the lack of robust reverse genetic systems, tissue culture and animal models limit the study of hCoV-HKU1 and hCoV-OC43 pathogenesis. Here, we examined the role of hCoV-HKU1 and hCoV-OC43 I proteins in pathogenesis using a prototypic coronavirus. We introduced the I proteins of hCoV-HKU1 and hCoV-OC43 independently to a neurotropic strain of mouse hepatitis virus (MHV-J2.2). MHV-J2.2 infection is well-characterized with clearly defined immune responses which allows the study of I proteins in the context of authentic coronavirus infection. We showed that the I protein of hCoV-HKU1 but not that of hCoV-OC43 ameliorated MHV-J2.2 infection while the I protein of MERS-CoV causes exacerbated disease. Further analysis revealed that infection with MHV-J2.2 expressing the I protein of MERS-CoV leads to increased neutrophil infiltration to the site of infection and virus titers in mice; diminished virus titers was observed in the presence of hCoV-HKU1 I protein. Overall, our findings suggest that the I protein of different betacoronaviruses play unique roles in pathogenesis.

2025-04-23 | GSE291309 | GEO

Proteogenomic of Blastocystis sp. subtype 4 isolate WR1

Project description:description Blastocystis sp. is a highly prevalent anaerobic eukaryotic parasite of humans and animals. The genome of several representatives has been sequenced revealing specific traits such as an intriguing 3’-end processing of primary transcripts. We have acquired a first high-throughput proteomics dataset on the difficult to cultivate ST4 isolate WR1 and detected 2,761 proteins. We evidenced for the first time by proteogenomics a functional termination codon derived from transcript polyadenylation for seven different key cellular components.

2017-09-11 | PXD006588 | Pride

Elizabethkingia bruuniana strain:patient | isolate:patient

Project description:Elizabethkingia bruuniana strain:patient | isolate:patient Genome sequencing

| PRJNA997111 | ENA

Leclercia adecarboxylata strain:patient | isolate:patient

Project description:Leclercia adecarboxylata strain:patient | isolate:patient Genome sequencing

| PRJNA559240 | ENA

Project description:WTCCC2 project Schizophrenia (SP) samples

| EGAD00010000262 | EGA

Streptococcus pneumoniae strain:HKU1-14

Project description:Streptococcus pneumoniae strain:HKU1-14 Genome sequencing and assembly

| PRJNA361421 | ENA

Comparing the transcriptome of SP cells with that of non-SP cells in rainbow trout

Project description:In rainbow trout, type A spermatogonia can be split into SP cells and non-SP cells by the ability to exclude Hoechst 33342 dye (H33342). The H33342 fluorescence of SP cells are lower than that of non-SP cells, after H33342 staining. To investigate whether SP cells were transcriptomically distinct from non-SP cells, we compared the transcriptome of these cells. We used fluorescence-activated cell sorting (FACS) to isolate SP cells and non-SP cells from the type A spermatogonia in rainbow trout.

2013-08-06 | GSE49565 | GEO

Klebsiella pneumoniae subsp. pneumoniae strain:patient isolate 1 | isolate:patient isolate 1

Project description:Klebsiella pneumoniae subsp. pneumoniae strain:patient isolate 1 | isolate:patient isolate 1 Genome sequencing

| PRJNA407665 | ENA