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Study on the mechanism of glycyrrhizic acid attenuating gefitinib-induced hepatotoxicity in mice

ABSTRACT: Study on the mechanism of glycyrrhizic acid attenuating gefitinib-induced hepatotoxicity in mice

PROVIDER: PRJNA941803 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23722702_1.fastq.gz	Fastqsanger.gz
	SRR23722702_2.fastq.gz	Fastqsanger.gz
	SRR23722703_1.fastq.gz	Fastqsanger.gz
	SRR23722703_2.fastq.gz	Fastqsanger.gz
	SRR23722704_1.fastq.gz	Fastqsanger.gz

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Study on the mechanism of glycyrrhizic acid attenuating gefitinib-induced hepatotoxicity in mice

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Glycyrrhizic acid improves cognitive levels of aging mice by regulating T/B cell proliferation

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Analysis of gene expression change by gefitinib treatment in gefitinib sensitive PC9 and resistant PC9.

Project description:We established a gefitinib-resistant cell line (PC-9GR), by serial exposure of gefitinib to PC-9, an originally gefitinib-sensitive lung cancer cell line (PC-9na), for long period.We collected total RNA from both PC-9 and PC-9GR and examined mRNA expression profile, comprehensively. Gefitinib induced gene expression was measured in human lung cancer cell line was measured at 48 hours after exposure to 1uM Gefitinib.

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Project description:Total gene expression difference after treatment gefitinib for 24 h compared to control NSCLCs To determine which proteins are responsible for the differences in glutamine metabolism in response to the gefitinib treatment between gefitinib-sensitive and gefitinib-resistant cells

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Project description:Compound Kushen Injection (CKI) has been used in clinics for nearly 20 years to treat different kinds of cancers. In this study, we found that CKI inhibited gefitinib resistant cell line proliferation, reduced drug resistance and improved anti-cancer effects when associated with gefitinib in a dose-dependent fashion. We also identified candidate CKI associated molecular mechanisms that might reduce drug resistance using transcriptome analysis methods, including gene differential expression analysis and pathway over-representation analysis. Multiple pathways were perturbed and the PI3K/AKT/MTOR and autophagy pathways were identified as the potential primary target pathways of CKI in this context. We also investigated the molecular mechanisms of another TCM, Yifei-Sanjie Wan (YFSJ) on reducing gefitinib resistance using transcriptome analysis.

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