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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChiRP-Seq]

ABSTRACT: Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChiRP-Seq]

PROVIDER: PRJNA947106 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23928376.fastq.gz	Fastqsanger.gz
	SRR23928377.fastq.gz	Fastqsanger.gz
	SRR23928378.fastq.gz	Fastqsanger.gz
	SRR23928379.fastq.gz	Fastqsanger.gz
	SRR23928380.fastq.gz	Fastqsanger.gz

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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChiRP-Seq]

Project description:A growing number of studies describe multiple functions of lncRNAs in chromatin that support their active roles in normal and disease-specific gene expression. We identified a specific enhancer-associated LINC01116 (named HOXDeRNA), which targeted activation transformed human astrocytes into glioma-like cells. Using a combination of RNA-Seq, ChIRP-Seq, and ChIP-Seq, we defined the transcriptomic and epigenetic changes underlying the transformation. We demonstrate that HOXDeRNA binds in trans to the promoters of 44 glioma-specific transcription factors distributed throughout the genome and derepresses them by removing the Polycomb 2 complex. This process is mediated by the RNA G-quadruplex structure of HOXDeRNA. Moreover, HOXDeRNA-induced astrocyte transformation is accompanied by the activation of glioma-specific super-enhancers enriched for binding sites of glioma master transcription factors SOX2 and OLIG2, and multiple oncogenes such as EGFR, PDGFR, BRAF, and miR-21. Our results help reconstruct the sequence of events underlying the process of astrocyte transformation and suggest a driving role of HOXDeRNA eRNA in gliomagenesis.

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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChIP-seq]

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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA

Project description:Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA

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Project description:Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [RNA-seq]

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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChIP-seq]

Project description:Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA [ChIP-seq]

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Genome-wide activation of a glioma cancerous transcription program and super-enhancers by a single enhancer HOXDeRNA

Project description:This SuperSeries is composed of the SubSeries listed below.

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