Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

ABSTRACT: The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

PROVIDER: PRJNA949228 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR23982923_1.fastq.gz	Fastqsanger.gz
	SRR23982923_2.fastq.gz	Fastqsanger.gz
	SRR23982925_1.fastq.gz	Fastqsanger.gz
	SRR23982925_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

Project description:In this study, osteocytes were proved to be capable of delivering mitochondria to endothelial cells in cortical bone and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells.

2025-06-18 | GSE228304 | GEO

Single-cell RNA-sequencing of osteocyte-derived mitochondria recipient cells in the intra-tibial injection of LLC1 cells murine model.

Project description:LLC1 cells were injected into the tibia of DMP1-Cre PhAM mice to study the intercellular mitochondrial transfer in the bone microenvironment. We used single-cell RNA sequencing (scRNA-seq) to analyze the cellular heterogeneity of osteocyte-derived mitochondria recipient cells.

2024-01-01 | GSE228613 | GEO

Small RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide

Project description:Numerous miRNAs have been found in mitochondria and these mitochondrial miRNAs have been shown important roles in many physiological and pathophysiological processes. However, the dynamic changes of miRNA distribution in mitochondria in the endothelial oxidative injury are still unclear. Therefore, miRNAs levels in whole cells and mitochondria of hydrogen peroxide treated endothelial cells for 12h and 18h were analyzed by small RNA sequencing.

2023-10-31 | E-MTAB-9851 | biostudies-arrayexpress

mRNA expression in endothelial cells stimulated with isolated mitochondria

Project description:Purpose: To compare gene expression profiles in endothelial cells stimulated with mitochondria isolated from vehicle-(MitoCo) or LPS-activated(MitoStress) THP-1 cells. Result: We identified Type I Interferon and TNF pathways induced by mitochondria isolated from activated cells.

2021-04-01 | GSE130225 | GEO

Osteocytes regulate transcortical blood vessel network by transferring mitochondria to endothelial cells in cortical bone

Project description:In this study, mitochondria were proved to be capable of delivering mitochondria to endothelial cells of transcortical blood vessel and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells.

2025-02-08 | GSE224786 | GEO

mRNA expression in endothelial cells stimulated with isolated mitochondria

Project description:mRNA expression in endothelial cells stimulated with isolated mitochondria

| PRJNA534320 | ENA

Control ChIP-seq from osteocyte (ENCSR702WFF)

Project description:Control ChIP-seq on osteocyte originated from osteocyte For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-03-29 | GSE169778 | GEO

TF ChIP-seq from osteocyte (ENCSR300DWM)

Project description:CTCF ChIP-seq on osteocyte originated from osteocyte For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-05-23 | GSE175159 | GEO

Osteoblast and Osteocyte Profiles at Different Cell-cummunication Status

Project description:Type of Experiment: 1) Profiles of Osteoblast vs. osteocyte in vitro; 2) Profiles of osteoblast low density vs. confluency in vitro; 3) Profiles of osteocyte with gap junction vs. without gap junction. Experimental factors: 1) 2T3 osteoblast cells at low density expressed extensive filopodia, reminiscent of early osteoblast precursors and similar to MLO-Y4 dendritic processes. 2) MLO-Y4 osteocytes at low vs. high density represent the genes that are changed in a highly connected network vs. low connected network. The number of hybridizations performed: Triplicate hybridizations for each status. Keywords = Osteoblast Keywords = Osteocyte

2010-06-09 | E-GEOD-2234 | biostudies-arrayexpress

Role of Piezo1-mediated mechanotransduction in osteocyte differentiation

Project description:Mechanical force is a fundamental regulator of bone development and homeostasis. Mechanosensitive osteocytes are the most abundant bone cells that form interconnected dendrites to respond to mechanical stimuli and interact with the bone-forming osteoblasts and the bone-remodeling osteoclasts. However, the molecular mechanisms underlying osteocyte maturation and dendrite formation remain unclear. By generating a Piezo1 "knock-out" osteocyte cell line, we identified a key role of Piezo1-mediated mechanotransduction in osteocyte differentiation. QRT-PCR analysis revealed delayed osteocyte differentiation in the Piezo1 KO cells relative to WT cells. By performing bulk RNA sequencing of WT and Piezo1 KO OCY454 cells at early (D1), intermediate (D14), and late (D28) stages of differentiation allowed for the identification of key signaling pathways in driving normal osteocyte dfiferentiation, as well as those regulated by Piezo1 mechanotransduction.

2024-09-20 | GSE277264 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data