Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic characterization of hepatobiliary plasticity of hepCLiPs and bilCLiPs

ABSTRACT: Transcriptomic characterization of hepatobiliary plasticity of hepCLiPs and bilCLiPs

PROVIDER: PRJNA954855 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24149400_1.fastq.gz	Fastqsanger.gz
	SRR24149400_2.fastq.gz	Fastqsanger.gz
	SRR24149401_1.fastq.gz	Fastqsanger.gz
	SRR24149401_2.fastq.gz	Fastqsanger.gz
	SRR24149402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Transcriptomic characterization of hepatobiliary plasticity of hepCLiPs and bilCLiPs

Project description:Recent studies have demonstrated extensive proliferative capacity of adult hepatocytes and biliary epithelial cells (BECs) in vitro, thereby allowing derivation of clonal cell lines named hepCLiPs and bilCLiPs, respectively. Both cell lines undergo hepatobiliary plastiticity in that they exhibit a BEC-like phenotype under a 2D culture condition, while they exhibit a hepatocyte-like phenotype under a 3D culture condition. This data set was obtained to comprehensively characterize the gene expression profiles of hepCLiPs and bilCLiPs which were cultured under 2D and 3D culture conditions.

2023-06-01 | GSE229543 | GEO

Proteomic Analysis of Canine Hepatobiliary Neuroendocrine Neoplasms

Project description:Neuroendocrine neoplasms of the gallbladder and liver occur rarely in dogs and humans. A recent reclassification of human neuroendocrine neoplasms by the World Health Organization has refined categorization of these tumors by morphology, replicative indices, and molecular signatures. In humans, these factors correlate with survival outcomes. Improved characterization of these tumors is needed in dogs to identify diagnostic biomarkers and determine therapeutic strategies. To achieve this objective, the proteome of 3 canine hepatobiliary neoplasms was compared to normal canine adrenal and liver tissue from formalin-fixed paraffin-embedded samples. Thirty-two upregulated and 121 downregulated differentially expressed proteins were identified in the hepatobiliary neuroendocrine neoplasm samples. Among the upregulated proteins is galectin-1, a multivalent carbohydrate binding protein known to play a role in lung and pancreatic neuroendocrine neoplasia development and progression in humans. Drugs targeting the galectin family have shown promise as anticancer therapeutics in cervical cancer, prostate cancer, lung and pancreatic neuroendocrine neoplasia in human medicine. Galectin-1 may represent a novel treatment target in hepatobiliary neuroendocrine neoplasia in both humans and dogs.

2023-03-11 | PXD028822 | Pride

E-GEOD-55048

Project description:Transcriptomic characterization of Hepatocellular Carcinoma with CTNNB1 mutation

2025-01-24 | E-GEOD-55048 | ExpressionAtlas

Plasma Proteome for Hepatobiliary Carcinomas

Project description:This project is to identify plasma glycoprotein markers for hepatobiliary cancers

2019-11-12 | PXD013629 | Pride

Plasma Proteome for Hepatobiliary Carcinomas

Project description:This project is to identify plasma glycoprotein markers for hepatobiliary cancers

2020-08-31 | MSV000086047 | MassIVE

Characterizing transcriptomic changes at different stage of hepatobiliary reprogramming in the adult mouse liver

Project description:Characterizing transcriptomic changes at different stage of hepatobiliary reprogramming in the adult mouse liver

| PRJNA906173 | ENA

Transcriptomic Characterization of wilms tumor

Project description:Transcriptomic Characterization of wilms tumor

| PRJNA577648 | ENA

Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity

Project description:Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic transmission through negative feedback mechanisms. However, identifying and characterizing novel molecular targets orchestrating synaptic plasticity remains a significant challenge. This study investigated the effects of tetrodotoxin (TTX)-induced synaptic plasticity within organotypic entorhino-hippocampal tissue cultures, offering insights into the functional, transcriptomic, and proteomic changes associated with network inhibition via voltage- gated sodium channel blockade. Our experiments demonstrate that TTX treatment induces substantial functional plasticity of excitatory synapses, evidenced by increased miniature excitatory postsynaptic current (mEPSC) amplitudes and frequencies in both dentate granule cells and CA1 pyramidal neurons. Correlating transcriptomic and proteomic data, we identified novel targets for future research into homeostatic plasticity, including cytoglobin, SLIT-ROBO Rho GTPase Activating Protein 3, Transferrin receptor, and 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1. These data provide a valuable resource for future studies aiming to understand the orchestration of homeostatic plasticity by metabolic pathways in distinct cell types of the central nervous system.

2025-05-07 | PXD056794 | Pride

E-GEOD-72590

Project description:Transcriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.

2019-05-14 | E-GEOD-72590 | ExpressionAtlas

Genomic and Transcriptomic characterization of chordoma

Project description:Genomic and Transcriptomic characterization of chordoma

| PRJNA478014 | ENA