Project description:Polyphenols are abundant in the raw materials (sorghum and wheat) used for sauce-flavor Baijiu fermentation, yet their interactions with the key brewing microorganism (Saccharomyces cerevisiae), remain poorly characterized. This study employed integrated transcriptomic and metabolomic approaches to investigate these interactions, revealing that major polyphenols had no significant impact on the growth kinetics of S. cerevisiae. Transcriptomic profiling identified 119 differentially expressed genes, comprising 90 up-regulated and 29 down-regulated genes. Genes associated with cell wall integrity, plasma membrane function, and transmembrane transport were significantly induced, indicating that S. cerevisiae adapts to polyphenolic stress through these pathways to maintain cellular homeostasis. Metabolomic analysis demonstrated efficient biotransformation of polyphenols during fermentation, with 22 polyphenols (e.g., naringin, taxifolin, caffeic acid) converted into 20 derivatives (e.g., 4-vinylphenol, benzoic acid). Integrated multi-omics analysis suggested that up-regulation of genes encoding oxidoreductases (e.g., OYE), esterases (e.g., EHT1), and hydrolases (e.g., EXG) might contribute to this bioconversion process. These findings elucidate the mechanistics interplay between polyphenols and S. cerevisiae, providing theoretical support for understanding the biochemical basis of sauce-flavor Baijiu fermentation.
2026-06-29 | MTBLS14885 | MetaboLights
Project description:Bacterial community during baijiu brewing at lab scale based on ZYL
| PRJNA872358 | ENA
Project description:Fungal community during baijiu brewing at lab scale based on ZYL
Project description:Rice is one of the main raw materials for Baijiu fermentation and plays an important role in the process of Baijiu brewing. Different varieties of rice may have different compositions of aroma substances in Baijiu due to different contents of physical and chemical components (amylopectin, tannin, fat, etc.), which may affect liquor quality. However, there is currently no systematic understanding of the differences in the types and contents of physicochemical components among different varieties of rice. This study mainly uses modern technological methods to conduct in-depth analysis and precise determination of the physicochemical components of different rice varieties, exploring the differences in physicochemical components of different rice varieties. This study will lay the foundation for the directional breeding of rice for liquor making, and strongly promote the Baijiu industry to accurately screen rice raw materials with higher quality and adaptability.