Plasma miRNA as Potential Biomarkers for Hand-arm vibration disease
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PROVIDER: PRJNA964747 | ENA |
REPOSITORIES: ENA
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Project description:MicroRNAs (miRNAs) have an essential function as post-transcriptional regulators in a variety of processes. miRNAs involvement and variation have mainly been studied in various disorders. Our study is the first to evaluate miRNA expression in hand-arm vibration disease (HAVD), an increasing occupational disease in China and the rest of the world. HAVD can cause injuries in microcirculation in the fingertip and induce the vibration-induced white finger (VWF), which can negatively affect patients’ quality of life. In this current study, we aimed to explore the mechanisms of development and progression of HAVD. We extracted total RNAs from the plasma of 24 metal workers and divided them into 3 groups: workers who reported VWF, workers exposed with occupational hand-transmitted vibration (HTV) without VWF, and control group. Genome-wide microarray gene chip was used to acknowledge the different miRNAs expression profiles. Functional analyses were operated to predict how those miRNAs work in VWF.
2025-06-30 | GSE231390 | GEO
Project description:Plasma miRNAs as biomarkers of epilepsy
| PRJNA1009812 | ENA
Project description:ObjectiveTo investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.MethodsThe study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with gas chromatography time-of-flight mass spectrometry. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.ResultsTwenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from participants without VWF, both before and after vibration exposure.ConclusionMetabolites that differed between the groups were identified both before and after exposure. Some of these metabolites might be indicators of health effects from exposure to vibrations. This is the first time that a metabolomic approach has been used in workers exposed to vibrations.
| S-EPMC7337105 | biostudies-literature
Project description:Brain expression profiling of bees perfroming consistently vibration signal (modulatory signal that stimulates the performance of several different activities in the hive).
2009-07-01 | E-TABM-608 | biostudies-arrayexpress
Project description:ObjectiveEpidemiology suggests that occupational exposure to hand-transmitted (segmental) vibration has local and systemic effects. This study used an animal model of segmental vibration to characterize the systemic effects of vibration.MethodsMale Sprague Dawley rats were exposed to tail vibration for 10 days. Genes indicative of inflammation, oxidative stress, and cell cycle, along were measured in the heart, kidney, prostate, and liver.ResultsVibration increased oxidative stress and pro-inflammatory gene expression, and decreased anti-oxidant enzymes in heart tissue. In the prostate and liver, vibration resulted in changes in the expression of pro-inflammatory factors and genes involved in cell cycle regulation.ConclusionsThese changes are consistent with epidemiological studies suggesting that segmental vibration has systemic effects. These effects may be mediated by changes in autonomic nervous system function, and/or inflammation and oxidative stress.
| S-EPMC6173648 | biostudies-literature
Project description:We used microarrays to perform systematic profiling of human microRNAs in plasma from nasopharyngeal carcinoma (NPC) patients to find potential biomarkers. By comparing the plasma microRNA profiles of the NPC patients and healthy donors, potential biomarkers for NPC were investigated. A total of 39 microRNAs were aberrantly expressed based on 50 Agilent microarrays containing 887 human microRNAs 50 microarrays containing 887 human microRNAs were used to screen for potential biomarkers with significant differential expression levels between 31 NPC patients and 19 healthy donors.
2013-08-01 | E-GEOD-43329 | biostudies-arrayexpress
Project description:Occupational exposure to vibration using hand-held tools may cause hand-arm vibration syndrome (HAVS) among workers. We report the case of a 39-year-old lady with a 5-year work exposure to repetitive wrist movements and vibration from hand tools in the dental fabrication laboratory, working as a dental technician. She presented with a 3-year history of chronic pain over the wrists and positive symptoms of numbness and tingling in the hands, pain and discomfort of the fingers during cold exposure, and poor grip strength. Symptoms over the right hand were worse than the left. She is right-hand dominant. She had bilateral median nerve neuropathy at the wrist. Nerve conductive tests were consistent with minimal bilateral carpal tunnel syndrome. MRI showed evidence of soft tissue damage from repetitive strain injury of the right wrist. Neurosensory grading for hand-vibration syndrome (HAVS) using the Stockholm Workshop Scale (SWS) was performed and she was graded as Stage 1SN with numbness or tingling symptoms. Using the International Consensus Criteria (ICC) grading for HAVS, she was graded Stage N1 with numbness and/or tingling (symptoms) of finger. A workplace risk health assessment (WHRA) was performed, and exposure scores for her work tasks in dental fabrication and risk levels were determined using the HSE (Health and Safety UK) Assessment of Repetitive Tasks (ART) tool. The processes of teeth setting using dental burs (exposure score 23), divestment work with stone clippers (score 20), and use of pneumatic drills (score 21) were deemed high-risk activities for repetitive strain injury. The use of carving tools (score 12), packing with the use of flask clamps, and trimming (score 14) were classified as medium high-risk activities for repetitive strain injuries. Workplace modifications and workplace vibration exposure level monitoring protocols were subsequently established with the stabilization of the patient's symptoms.
| S-EPMC11473303 | biostudies-literature
Project description:We used a novel approach to study the acute effect of three physiologic stressors (active contractions, vibration, and systemic heat stress) in human skeletal muscle. Three hours after the completion of a dose of physiologic stress, we sampled the soleus (contraction and vibration) or vastus lateralis (heat) muscle and developed a unique gene expression signature for each stressor. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold change), PGC-1α (5.46 fold change), and ABRA (5.98 fold change); and repressed MSTN (0.56 fold change). Heat stress repressed PGC-1α (0.74 fold change); while vibration induced FOXK2 (2.36 fold change). Vibration similarly caused a down regulation of MSTN (0.74 fold change), but to a lesser extent than active muscle contraction. Vibration induced FOXK2 while heat stress repressed PGC-1α (0.74 fold change) and ANKRD1 genes (0.51 fold change). These findings support a distinct gene regulation in response to heat stress, vibration, and muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell development, growth, and repair.
2017-02-09 | GSE82323 | GEO
Project description:The some biomarkers can be found by pairwise comparison. They can distinguish between extremely severe Hand,foot and mouth disease and mild Hand,foot and mouth disease,moreover,they can applied to diagnose extremely severe Hand,foot and mouth disease mild Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.mild Hand,foot and mouth disease,verification by qRT-PCR
2013-11-27 | E-GEOD-52780 | biostudies-arrayexpress
Project description:The some biomarkers can be found by pairwise comparison. They can distinguish between extremely severe Hand,foot and mouth disease and mild Hand,foot and mouth disease,moreover,they can applied to diagnose extremely severe Hand,foot and mouth disease
2013-11-27 | GSE52780 | GEO