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Plasma miRNA as Potential Biomarkers for Hand-arm vibration disease

ABSTRACT: Plasma miRNA as Potential Biomarkers for Hand-arm vibration disease

PROVIDER: PRJNA964747 | ENA |

REPOSITORIES: ENA

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Plasma miRNA as Potential Biomarkers for Hand-arm vibration disease

Project description:MicroRNAs (miRNAs) have an essential function as post-transcriptional regulators in a variety of processes. miRNAs involvement and variation have mainly been studied in various disorders. Our study is the first to evaluate miRNA expression in hand-arm vibration disease (HAVD), an increasing occupational disease in China and the rest of the world. HAVD can cause injuries in microcirculation in the fingertip and induce the vibration-induced white finger (VWF), which can negatively affect patients’ quality of life. In this current study, we aimed to explore the mechanisms of development and progression of HAVD. We extracted total RNAs from the plasma of 24 metal workers and divided them into 3 groups: workers who reported VWF, workers exposed with occupational hand-transmitted vibration (HTV) without VWF, and control group. Genome-wide microarray gene chip was used to acknowledge the different miRNAs expression profiles. Functional analyses were operated to predict how those miRNAs work in VWF.

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Project description:We used a novel approach to study the acute effect of three physiologic stressors (active contractions, vibration, and systemic heat stress) in human skeletal muscle. Three hours after the completion of a dose of physiologic stress, we sampled the soleus (contraction and vibration) or vastus lateralis (heat) muscle and developed a unique gene expression signature for each stressor. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold change), PGC-1α (5.46 fold change), and ABRA (5.98 fold change); and repressed MSTN (0.56 fold change). Heat stress repressed PGC-1α (0.74 fold change); while vibration induced FOXK2 (2.36 fold change). Vibration similarly caused a down regulation of MSTN (0.74 fold change), but to a lesser extent than active muscle contraction. Vibration induced FOXK2 while heat stress repressed PGC-1α (0.74 fold change) and ANKRD1 genes (0.51 fold change). These findings support a distinct gene regulation in response to heat stress, vibration, and muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell development, growth, and repair.

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