Project description:MC38 tumors resistant to anti-PD-1 treatment (MC38-resistant) were generated through serial in vivo passaging, and global gene expression analysis was used to compare resistant and parental tumors. MC38 and MC38-resistant tumors exhibited widespread changes in global gene expression.
Project description:Parental MC38 tumor cells were transduced with the STING-N153S mutant and RNA-seq for differential gene expression analysis was performed
Project description:In this study, we used bulk RNA-seq to to comprehensively compare gene expression in wild-type and Npm1-deficient tumor cells isolated from MC38 tumor tissues.
Project description:To characterize the role of Pglyrp1 in tumor immunity, we performed bulk RNA-seq for MC38-OVA tumor infiltrating CD8+ T cells from wild type and Pglyrp1-deficient mice.
Project description:This study investigates the dynamics of thymic dendritic cells (DCs) under tumor-bearing conditions and the role of CCR9 in regulating thymic DC homeostasis. CD11c⁺ thymic cells were enriched from wild-type (WT) and CCR9 knockout (CCR9 KO) mice subjected to different experimental treatments. Four experimental groups were analyzed: CCR9 WT mice treated with PBS for 2 weeks CCR9 WT mice bearing MC38 tumors for 2 weeks CCR9 WT mice bearing MC38 tumors for 3 weeks CCR9 KO mice bearing MC38 tumors for 3 weeks
Project description:Expression profile of parental wild type non-small cell lung cancer, NCI-H460, and cancer stem cell-rich (CSC-rich) populations treated with PNAs-A15 for 6 h. Results provide the information that PNAs-A15, a peptide nucleic acid of A-repeats length 15 bp, suppressed up-regulated A-repeats containing genes in both parental wild type and CSC-rich cells.