Project description:BALF and plasma proteomic profiling from the Clinical Response in Pneumonia Therapy (SCRIPT) study which aims to improve treatment strategies for patients with severe pneumonia. The samples were obtained during the early stages of the COVID-19 pandemic (June 15th, 2018 - JulClinical Response in Pneumonia Therapy (SCRIPT) study which aims to improve treatment strategies for patients with severe pneumonia. The samples were obtained during the early stages of the COVID-19 pandemic (June 15th, 2018 - July 6th, 2020) and included patients facing respiratory failure requiring mechanical ventilation in the intensive care unit (ICU).
Project description:Description:
Mass spec raw data in association with Sudhakar JN, et al in Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas, Nat Comms (accepted 2020 July).
2020-07-27 | MSV000085831 | MassIVE
Project description:Oakley Mountain soil sample in July of 2018
Project description:Changes in sensory gene expression may underly seasonal changes in behavior. To accompany other research on seasonal changes in coloration and behavior in the seasonally plastic common buckeye butterfly Junonia coenia, we examined how gene expression in eyes differs between wild butterflies caught in summer and fall. We collected animals in 2019, 2020, and 2021 in the central United States. The samples consisted of three males and three females from each season: Summer (June/July) and Fall (late September/October) that had wing colors appropriate for previously described seasonal morphs (i.e. light in summer and dark in fall). We dissected eye tissue from butterfly heads and purified RNA prior to sending samples to Novogene for cDNA Library prep and RNA-Sequencing. We used DESeq2 for subsequent analysis. We found gene expression correlated to sex, season, and interactions between sex and season. Eye tissues from dark fall animals and light summer animals exhibit different patterns of expression in many genes including visual system development genes, pigmentation genes, and clock genes. This change in gene expression accompanies changes in basking behavior and wing color and indicates that J. coenia undergoes changes to its visual system depending on the seasonal environment.