Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Eliminating Malaria Vectors with Precision Guided Sterile Males

PROVIDER: PRJNA978105 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24780829_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 1 of 1

Similar Datasets

Project description:Eliminating Mosquito Populations with Precision Guided Sterile Males

| PRJNA699282 | ENA

Project description:Probiotic neoantigen delivery vectors for precision cancer immunotherapy

| PRJNA1024050 | ENA

Project description:Probiotic neoantigen delivery vectors for precision cancer immunotherapy

| PRJNA1025007 | ENA

Probiotic neoantigen delivery vectors for precision cancer immunotherapy

Project description:Probiotic neoantigen delivery vectors for precision cancer immunotherapy

| PRJNA1024935 | ENA

Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites

Project description:Attenuated whole organism vaccines targeting the malaria liver stage reliably confer sterile immunity. These vaccines can completely protect female mice from infection, but protection in male mice remains unproven. We discovered that male BALB/cJ mice vaccinated with prime-and-trap, a whole organism-based vaccine strategy, exhibit poorer protection against Plasmodium yoelii sporozoite challenge than females. We investigated this sex difference, and identified vaccinated males have fewer hepatic memory CD8+ T cells than females when scaling for differences in liver biomass, and reduced acute inflammatory responses post-vaccination. Surgical hormone manipulation clarified that the presence of testicular hormones, not the absence of ovarian hormones, hindered protection in male mice. The presence of androgens did not affect memory CD8+ T cells quantity nor quality of, but inhibited protective cellular responses during sporozoite challenge. Thus, both males and females form functional memory responses following prime-and-trap vaccination, but androgens during sporozoite challenge impair protection in male mice.

2025-04-04 | GSE253755 | GEO

Anopheles

Project description:Speciation and adaptation in human malaria mosquito vectors

| PRJNA273873 | ENA

Ceratitis capitata strain:GSS-Vienna8

Project description:Intestinal microbiota of Ceratitis capitata sterile males after probiotic feeding

| PRJNA954598 | ENA

Implication of small sperm RNAs in the inheritance of the effect of early traumatic stress in mice

Project description:Small non-coding RNAs (sncRNAs) have been proposed as potential vectors of the interface between genes and environment. Here, we report that environmental conditions involving traumatic stress in early life, alter miRNA and piRNA composition in sperm of adult males in mice.

2014-04-13 | GSE50132 | GEO

Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor [ChIP-Seq]

Project description:Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. In this paper we report an AP2 family transcription factor AP2-FG is responsible for female-specific gene expression.

2019-05-05 | GSE114094 | GEO

A Safety and Efficacy Study of ChAd63/MVA METRAP + RTS,S

Project description:The goal of this phase 1/2a sporozoite challenge trial (NCT01883609) was to evaluate novel malaria vaccination regimens of the GSK pre-erythrocytic RTS,S/AS01B vaccine alone and concomitantly same-site administered with the viral vectors ChAd63 & MVA encoding the liver stage antigen construct ME-TRAP. Four vaccine groups were studied and received three vaccinations at a monthly interval. All subjects then underwent controlled human malaria infection (CHMI) 11 weeks after first vaccine administration.

2020-09-01 | GSE103862 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data