Rattus norvegicus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA97887 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Microarray of human primary CD16+ monocytes treated with fractalkine (CX3CL1) against untreated controls
2025-01-23 | E-MTAB-7484 | ExpressionAtlas
Project description:Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. We have identified fractalkine as a possible novel mediator in HF development. To address this issue, we have performed microarray analysis of cardiomyocytes treated with different isoforms of fractalkine. Methods: Cardiomyocytes isolated from adult rat hearts and treated with different forms of fractalkine for 24 hours. Control cells were treated with BSA. Molecular alterations in myocardial tissue were measured by using cDNA microarrays. Molecular pathways affected were identified by the Ingenuity Pathway Analysis software. Results: Several molecular pathways were affected upon fractalkine stimulation of adult cardiomyocytes. Experiment Overall Design: Cardiomyocytes isolated from adult rat hearts at three different timepoints. Five fractalkine treated samples and five control samples were pairwise analyzed. The cells were from three different isolations. Treated and untreated cells from the same isolation were compared on each microarray.
2008-06-18 | E-GEOD-7397 | biostudies-arrayexpress
Project description:Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. We have identified fractalkine as a possible novel mediator in HF development. To address this issue, we have performed microarray analysis of cardiomyocytes treated with different isoforms of fractalkine. Methods: Cardiomyocytes isolated from adult rat hearts and treated with different forms of fractalkine for 24 hours. Control cells were treated with BSA. Molecular alterations in myocardial tissue were measured by using cDNA microarrays. Molecular pathways affected were identified by the Ingenuity Pathway Analysis software. Results: Several molecular pathways were affected upon fractalkine stimulation of adult cardiomyocytes. Keywords: Fractalkines effect on cardiomyocytes
2008-02-01 | GSE7397 | GEO
Project description:MicroRNA expression in neonatal and adult rat cardiomyocytes
| PRJNA177383 | ENA
Project description:This experiment is a part of the larger study on angiotensin II role in the upregulation of the CX3CL1 expression and its release in human first trimester placenta. CX3CL1 (or fractalkine) is chemokine involved in the pathogenesis of hypertension, which can be secreted by trophoblasts, initiating the cross talk with monocytes. Thus, we performed the microarray experiment to study the effects of recombinant human CX3CL1 on the transcriptome of human primary monocytes.
2019-02-08 | E-MTAB-7484 | biostudies-arrayexpress
Project description:Gene expression data from corticosteroid-treated neonatal rat cardiomyocytes
| PRJNA111005 | ENA
Project description:miRNA profiling in adult rat cardiomyocytes and myocyte-derived progenitor cells
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Project description:Leptin and fractalkine: Novel subcutaneous cytokines in burn injury.
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Project description:Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids
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Project description:This SuperSeries is composed of the SubSeries listed below.
2015-01-01 | GSE58692 | GEO