Project description:This study investigated whether the human feces-derived candidate probiotic Weissella confusa Wc1982 ameliorates high-fat diet-induced hyperlipidemia in Golden Syrian hamsters and characterized the associated hepatic transcriptional responses. Male LVG hamsters received a normal diet, a high-fat diet, or a high-fat diet plus oral Wc1982 (5 × 10^8 CFU/day) for six weeks. Liver RNA sequencing showed that Wc1982 increased expression of genes involved in PPARα-regulated fatty acid uptake, fatty acid oxidation, and ketogenesis, while reducing expression of canonical and non-canonical NF-κB pathway genes and fibrosis-related genes. The dataset contains raw gene-level counts and FPKM-normalized expression values for 18 liver samples.

2026-06-30 | GSE336151 | GEO

Weissella confusa

Project description:Weissella confusa Genome sequencing and assembly

| PRJNA436478 | ENA

Weissella confusa strain:JLP1 | isolate:feces

Project description:Weissella confusa strain:JLP1 | isolate:feces Genome sequencing

| PRJNA1146947 | ENA

Weissella confusa strain:LM1 | isolate:Monoisolate

Project description:Weissella confusa strain:LM1 | isolate:Monoisolate Genome sequencing

| PRJNA752246 | ENA

Weissella confusa strain:UMPC2 | isolate:UMPC2

Project description:Weissella confusa strain:UMPC2 | isolate:UMPC2 Genome sequencing