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Weissella confusa Wc1982 ameliorates hyperlipidemia through gut microbiota remodeling and hepatic PPARα/NF-κB signaling in hamsters

ABSTRACT: This study investigated whether the human feces-derived candidate probiotic Weissella confusa Wc1982 ameliorates high-fat diet-induced hyperlipidemia in Golden Syrian hamsters and characterized the associated hepatic transcriptional responses. Male LVG hamsters received a normal diet, a high-fat diet, or a high-fat diet plus oral Wc1982 (5 × 10^8 CFU/day) for six weeks. Liver RNA sequencing showed that Wc1982 increased expression of genes involved in PPARα-regulated fatty acid uptake, fatty acid oxidation, and ketogenesis, while reducing expression of canonical and non-canonical NF-κB pathway genes and fibrosis-related genes. The dataset contains raw gene-level counts and FPKM-normalized expression values for 18 liver samples.

ORGANISM(S): Mesocricetus auratus

PROVIDER: GSE336151 | GEO | 2026/06/30

REPOSITORIES: GEO

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