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Homo sapiens

ABSTRACT: Cultured A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050

OTHER RELATED OMICS DATASETS IN: E-GEOD-6400

PROVIDER: PRJNA99711 | ENA |

REPOSITORIES: ENA

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E-GEOD-6400

Project description:Transcription profiling of human A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050 a new class of tumor-selective inhibitors of gene expression.

2025-01-24 | E-GEOD-6400 | ExpressionAtlas

Transcription profiling of human A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050 a new class of tumor-selective inhibitors of gene expression.

2007-10-26 | E-GEOD-6400 | biostudies-arrayexpress

Cultured A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050

Project description:The goal of this project was to characterize changes in gene expression in response to the anti-cancer agent sapphyrin PCI-2050. Cultured A549 human lung cancer cells were treated with sapphyrin PCI-2050 or actinomycin D, a known transcripitonal inhibitor. The gene expression profiles of drug-treated and control A549 cultures were determined using Human Genome U133 Plus 2.0 Arrays (Affymetrix, Santa Clara, CA). Further details are provided in our published manuscript: <http://www.molecular-cancer.com/content/6/1/9>. Keywords: responses to treatments with anti-cancer agents

2006-12-01 | GSE6400 | GEO

E-GEOD-26525

Project description:Expression data analyzed with LPIA in A549 lung carcinoma cells treated with geldanamycin.

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E-MTAB-5627

Project description:Microarray analysis of human A549 lung cancer cells treated with brefeldin A, golgicide A, monensin or vehicle control for 8 h or 20 h

2025-01-23 | E-MTAB-5627 | ExpressionAtlas

E-GEOD-39733

Project description:Microarray analysis of gene expression changes in human A549 lung cancer cells upon siRNA knockdown of FAM60A and SDS3

2025-01-24 | E-GEOD-39733 | ExpressionAtlas

E-GEOD-2189

Project description:Transcription profiling of human lung cancer cell A549 lines treated with the chemotherapeutic drug motexafin gaolinium at 4, 12 and 24h timepoints

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E-GEOD-50627

Project description:transcription profiling by array of stem cells isolated from non-small cell lung cancer cell lines (NCI-H2170 and A549) and normal lung epithelial cell line (PHBEC)

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E-GEOD-26241

Project description:Expression data from TGFbeta-treated control or aPKC silenced A549 cells

2025-01-24 | E-GEOD-26241 | ExpressionAtlas

Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores 1

Project description:We have shown that water solubilized versions of a zinc ionophore increase intracellular concentrations of free zinc and have antiproliferative activity in exponential phase A549 lung cancer cultures. The gene expression profiles of A549 lung cancer cultures treated with the lead compound PCI-5002 reveal the activation of stress response pathways. Medium supplementation with zinc (25 μM) led to activation of additional oxidative stress response as well as apoptotic pathways. We propose that the pharmacologic delivery of zinc to tumors using water solubilized ionophores is a potential approach to cancer therapy. Keywords: Dose response

2007-02-07 | GSE6960 | GEO

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