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ProteomicsControl of ciliary signaling by AKAP2
In this project, we identify AKAP2 as a novel ciliary protein that controls physiological events underlying cilium biogenesis, ciliary trafficking and signaling. To this end, we performed affinity purification of AKAP2 tagged with FLAG-STREP. A cell line with FLAG-STREP empty vector was used as nega...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD063616 | Pride
Lc-msms  akap2  cyclic amp  cilium  pka 
TranscriptomicsAKAP2 coordinates a focal adhesion signaling scaffold to promote growth and metastasis in triple-negative breast cancer
A Kinase Anchoring Proteins (AKAPs) that coordinate spatiotemporal signaling are increasingly implicated in cancer. Elevated AKAP2 protein correlates with an invasive phenotype in triple-negative breast cancer cell lines. A combination of biochemical, cellular, and omics approaches show that AKAP2 c...
ORGANISM(S): Homo sapiens 
2025-11-25 | GSE311243 | GEO
GenomicsAKAP2 coordinates a focal adhesion signaling scaffold to promote growth and metastasis in triple-negative breast cancer
AKAP2 coordinates a focal adhesion signaling scaffold to promote growth and metastasis in triple-negative breast cancer
PRJNA1368831 | ENA
UnknownCloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein.
Not available
S-EPMC30634 | biostudies-literature
UnknownStructure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.
Not available
S-EPMC3090270 | biostudies-literature
UnknownD-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
Not available
S-EPMC23409 | biostudies-literature
UnknownLack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population.
Not available
S-EPMC5571670 | biostudies-literature
UnknownD-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold.
Not available
S-EPMC4282416 | biostudies-literature
UnknownAKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.
Not available
S-EPMC3272850 | biostudies-literature
UnknownProteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton.
Not available
S-EPMC11403584 | biostudies-literature
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