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MetabolomicsAssociation between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights
MetabolomicsEngineered Bacillus subtilis WB600/ZD reduces post-weaning diarrhea in piglets by modulating gut microbiota and aryl hydrocarbon receptor (AHR) signaling

Post-weaning diarrhea (PWD) causes significant economic losses to the pig farming industry. Our previous study demonstrated that the engineered Bacillus subtilis WB600/ZD (an engineered Bacillus subtilis strain expressing the antimicrobial defensin peptide from Zophobas atratus), alleviates intes...

2025-08-15 | MTBLS12862 | MetaboLights
MetabolomicsMetabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice (Part II)
Not available
ORGANISM(S): Mus musculus 
ST000233 | MetabolomicsWorkbench
MetabolomicsMetabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice (Part I)
Not available
ORGANISM(S): Mus musculus 
ST000226 | MetabolomicsWorkbench
MetabolomicsUrolithin A (UroA) acts at CYP1A1/1B1 substrates leading to enhanced aryl hydrocarbon receptor (AHR) activity in vivo
Not available
ORGANISM(S): Mus musculus 
ST002481 | MetabolomicsWorkbench
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries
This SuperSeries is composed of the following subset Series: GSE15857: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney GSE15858: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-15859 | biostudies-arrayexpress
TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
TranscriptomicsMast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
We found that AhR, a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. This study seeks to further the understanding of the mechanisms of how AhR control mast cell homeostasis. Three different batches of bone marrow derived mast c...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44715 | biostudies-arrayexpress
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [RNA-Seq]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-47944 | biostudies-arrayexpress
ProteomicsAryl hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis
Aryl hydrocarbon receptor-interacting protein (AIP), a putative positive intermediary in aryl hydrocarbon receptor-mediated signaling, is overexpressed in highly metastatic human KM12SM CRC cells, with high metastatic capacity to liver, and other highly metastatic CRC cells. Meta-analysis and immuno...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD031119 | Pride
Colorectal cancer Aip Liver metastasis Cancer proteomics Aryl hydrocarbon receptor-interacting protein Cadherin-17 
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