In order to detect the alteration in the transcriptomic profile of fibroblasts exposed to the large oncosomes and detemine the transcription factor responsible for those alteration we performed whole RNA sequncing with and without treatment with large oncosomes. Deep sequencing data were generated i...
Here, we tested the effects of a specific population of large extracellular vesicles (EVs), large oncosomes (LO) isolated from the bone marrow of mice with B-cell acute lymphoblastic leukemia (B-ALL) on primary mesenchymal stromal cells (MSCs).
Extracellular vesicles (EVs) are membranous structures of variable size, shed from diverse cell types including highly invasive, fast migrating, amoeboid tumor cells. Silencing of the Diaphanous-related formin-3 (DIAPH3) protein in DU145 prostate cancer cells induces an amoeboid phenotype characteri...
Glioblastoma (GBM) is the most aggressive and common malignant brain tumor in adults. GBMs are characterized by high intratumor heterogeneity and by the presence of the cancer stem cell niche. The vacuolar ATPase (V-ATPase) is a multisubunit proton pump that plays a role in multiple processes in euk...
