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ProteomicsABIN1 is an signal-induced autophagy adaptor counteracting LUBAC-mediated linear ubiquitination
ABIN1 KO RAW264.7 cells and stably reconstituted with 3×FLAG-ABIN1 WT or D485N were subjected to mass spectrometric analysis. Three biological replicates were prepared for each condition. Cells were stimulated for 3 hours with 100 ng/ml LPS. ABIN1 was immunoprecipitated with 30 uL anti-FLAG M2 Magne...
ORGANISM(S): Mus Musculus (mouse) 
2022-02-17 | PXD024864 | JPOST Repository
TranscriptomicsRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
We have previously generated ABIN1[D485N] knock-in mice that appear relatively normal for 2 months after birth, but develop large spleen at 3 months, which is followed by the appearance of high levels of antibodies against self DNA and self-nuclear antigens and severe inflammation of the kidney and ...
ORGANISM(S): Mus musculus 
2019-11-04 | E-MTAB-8185 | biostudies-arrayexpress
GenomicsABIN1 is a negative regulator of effector functions in cytotoxic T cells
ABIN1 is a negative regulator of effector functions in cytotoxic T cells
PRJNA1028272 | ENA
TranscriptomicsABIN1 is a negative regulator of effector functions in cytotoxic T cells
The main objective of the data analysis presented here is the investigation of the role of ABIN1 in antigenic responses of primary T cells. For this purpose, T cells from ABIN1-deficient mouse strain (GTKO) and WT mice were analyzed under different activation conditions. The effect of P38 MAPK inhib...
ORGANISM(S): Mus musculus 
2023-11-01 | GSE245397 | GEO
UnknownABIN1 dysfunction as a genetic basis for lupus nephritis.
Not available
S-EPMC3810087 | biostudies-literature
ProteomicsAnalysis of GITR and OX40 signaling complexes
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-25 | PXD046422 | Pride
T cells  co-stimulation  gitr  ox40  abin1  ms 
GenomicsABIN1 (Q478) is required to prevent hematopoietic deficiencies through regulating type I IFNs expression
ABIN1 (Q478) is required to prevent hematopoietic deficiencies through regulating type I IFNs expression
PRJNA1026640 | ENA
UnknownABIN1 is a negative regulator of effector functions in cytotoxic T cells.
Not available
S-EPMC11315980 | biostudies-literature
GenomicsRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
RNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
PRJEB33670 | ENA
TranscriptomicsABIN1 (Q478) is required to prevent hematopoietic deficiencies through regulating type I IFNs expression
A20-binding inhibitor of NF-κB activation (ABIN1) is a polyubiquitin-binding protein that regulates cell death and immune responses. Although Abin1 (Tnip1) is located on chromosome 5q in the region commonly deleted in patients with 5q minus syndrome, the most distinct of the myelodysplastic syndrome...
ORGANISM(S): Mus musculus 
2023-10-15 | GSE245029 | GEO
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