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MetabolomicsThe accumulation of methylglyoxal and acrolein leads to arginine depletion causing hyperglycemia and renal abnormalities

There is growing evidence to support the idea that the accumulation of reactive carbonyl species plays a significant causal role in the pathogenesis of ageing, cardiovascular diseases, diabetes and its complications. Among reactive carbonyl species, methylglyoxal and acrolein, detoxified by glyox...

2026-06-17 | MTBLS14089 | MetaboLights
TranscriptomicsAcrolein-mediated changes in HUVEC miRNA
Acrolein is a major reactive component of vehicle exhaust, cigarette and wood smoke. It is also present in several food substances and is generated endogenously during inflammation and lipid peroxidation. Although previous studies have shown that dietary or inhalation exposure to acrolein results in...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 lung epithelial cells exposed to acrolein shows activation of early growth response genes dominate transcriptional responses
The transcriptional response of A549 lung cells to 100 micromolar acrolein exposure over a time course of 4 hours.
ORGANISM(S): Homo sapiens 
2008-06-01 | E-MEXP-1599 | biostudies-arrayexpress
ProteomicsAcrolein attached mouse cell LC-MS/MS
Dysregulated cell death leading to uncontrolled cell proliferation is a major hallmark of cancer. Chemotherapy-induced cell death is critical for the success of cancer treatment but this process is impaired by metabolic byproducts. How these metabolic byproducts interfere with the efficacies of anti...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD059944 | Pride
Mouse Cell Acrolein Lc-ms/ms 
ProteomicsProteomic analysis reveals shared biological pathways linking acrolein to biomolecular changes in the acute phase of rat spinal cord injury
Spinal cord injury (SCI) is a devastating and highly heterogeneous condition that often leads to permanent sensory, motor, and autonomic impairments. Beyond the initial mechanical trauma, a cascade of secondary biochemical events further amplifies tissue damage and functional loss. In this study, we...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-02 | PXD076398 | Pride
Spinal cord injury Proteomics Rat Acrolein 
ProteomicsDisruption of endothelial glycocalyx after ischemic stroke onset: Activated scission activity of proHPSE by acrolein exposure
Infiltration of peripheral immune cells after blood-brain barrier (BBB) dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx functions as a barrier to circulating cells, the relationship between stroke severity and glycocalyx dysfunction remains unclear. In this...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021040 | Pride
Acrolein heparanase 
ProteomicsPyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
This study used a proteomic approach with an anti-Acr-PC antibody followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify several acrolein-modified protein targets. Among these protein targets, pyruvate kinase M2 (PKM2) was found to be modified by acrolein at Cys35...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD040335 | Pride
Renal fibrosis  acrolein  pyruvate kinase m2  hypoxia-inducible factor 1-alpha  hydralazine  carnosine. 
GenomicsAcrolein-induced transcriptomic alterations in male Wistar-Kyoto rats
Acrolein-induced transcriptomic alterations in male Wistar-Kyoto rats
PRJNA1040189 | ENA
GenomicsAcrolein-mediated changes in HUVEC miRNA
Acrolein is a major reactive component of vehicle exhaust, cigarette and wood smoke. It is also present in several food substances and is generated endogenously during inflammation and lipid peroxidation. Although previous studies have shown that dietary or inhalation exposure to acrolein results in...
ORGANISM(S): Homo sapiens 
2014-06-03 | GSE56782 | GEO
GenomicsSpermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production
PRJNA1108754 | ENA
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