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MetabolomicsMulti-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...
2020-01-23 | MTBLS721 | MetaboLights
MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
MetabolomicsMTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes

To understand the molecular changes that underwrite enhanced mitochondrial respiration upon MTCH2 knockdown, we performed lipidomics profiling in hMADs adipocytes.

2025-08-04 | MTBLS12815 | MetaboLights
ProteomicsDual-Probe Activity-Based Protein Profiling Reveals Site-Specific Binding Dynamics of EGFR-Directed Drugs
Comparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD045864 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  concentration-dependent analysis  dual-probe comparison. 
ProteomicsSITE-SPECIFIC ACTIVITY-BASED PROTEIN PROFILING USING PHOSPHONATE HANDLES
Most drug molecules target proteins. Identification of the exact drug binding sites on these proteins is essential to understand and predict how drugs affect protein structure and function. To address this challenge, we developed a strategy that uses IMAC-enrichable phosphonate affinity tags, for ef...
ORGANISM(S): Homo sapiens (Human) 
2023-01-10 | PXD036569 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  phosphonate affinity handles  fe(iii)-immobilized metal affinity chromatography. 
ProteomicsDruggable Serine Proteases of Leishmania by Activity‐Based Protein Profiling
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of action, are urgently needed to treat the disease. Alt...
ORGANISM(S): Leishmania mexicana 
2022-07-04 | PXD033616 | Pride
Activity-based protein profiling Leishmania Serine protease 
ProteomicsDeubiquitinase Vulnerabilities Identified through Activity Based Protein Profiling in Non-Small Cell Lung Cancer
To aid in the prioritization of deubiquitinases (DUBs) as anticancer targets, we developed an approach combining activity-based protein profiling (ABPP) with mass spectrometry in both non-small cell lung cancer (NSCLC) tumor tissues and cell lines along with analysis of available RNA interference an...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD028802 | Pride
Human Activity-based protein profiling Deubiquitinase Lung cancer 
ProteomicsDeciphering Differential Gut Bacterial Drug Metabolism with Activity-Based Protein Profiling
Gut bacterial β-glucuronidases (GUS) promote the toxic side effects of therapeutics by reactivating drugs from their inactive glucuronide conjugates. It is increasingly clear that the interindividual variability of bacterial GUS-producing species in the gut microbiota contributes to differential dru...
ORGANISM(S): human gut metagenome 
2019-12-03 | PXD014864 | Pride
Drug metabolism Gut microbiome Activity-based protein profiling 
ProteomicsA General Approach for Activity-based Protein Profiling of Oxidoreductases with Redox-differentiated Diarylhalonium Warheads
Activity-based protein profiling (ABPP) is a unique proteomic tool for measuring the activity of enzymes in their cellular context, which has been well established for enzyme classes exhibiting a characteristic nucleophilic residue (e.g. hydrolases). In contrast, the enzyme class of oxidoreductases ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD043873 | Pride
Oxidoreductase probe Mouse liver; Activity-based protein profiling 
ProteomicsFunctional Mapping of the Trypanosoma cruzi Serinome by Fluorophosphonate Activity-Based Protein Profiling
Serine hydrolases (SHs) constitute one of the largest enzyme superfamilies in eukaryotes, yet their roles in Trypanosoma cruzi, the causative agent of Chagas disease, remain largely uncharacterized. Here, we report an activity-based chemoproteomic map of the T. cruzi epimastigote serinome by combini...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2026-07-21 | PXD080813 | Pride
Activity-based protein profiling Chagas disease Fluorophosphonate probes Serine hydrolases Trypanosoma cruzi 
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