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MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
TranscriptomicsInnate and adaptive immunity in zebrafish: time course (zebrafish)
The interaction between fungal pathogen and host innnate and adaptive immunity during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histolog...
ORGANISM(S): Danio rerio 
2014-11-03 | E-GEOD-51603 | biostudies-arrayexpress
MetabolomicsGut microbiota-derived butyrate primes systemic immunity in honeybees by mediating lipid metabolic reprogramming

The gut microbiota plays a crucial role in insect immune priming, inducing memory-like response that functionally resembles adaptive immunity confined to vertebrates. While gut microbiota mediates systemic immune activation in insect hemolymph, the mechanisms underlying remote immunoregulation re...

2025-10-07 | MTBLS13098 | MetaboLights
TranscriptomicsHuman keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-30355 | biostudies-arrayexpress
TranscriptomicsHosts responses in critical disease caused by pandemic H1N1
Critical disease caused by the new 2009 pandemic influenza virus (nvH1N1) is a challenge for physicians and scientist. As evidenced in SARS and H5N1, the development of an effective immune response plays a key role to overcome viral diseases. We studied host`s gene expression signatures, cytokine a...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-21802 | biostudies-arrayexpress
TranscriptomicsEarly specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses
T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combine single-cell gene expression analyses with...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54321 | biostudies-arrayexpress
TranscriptomicsA single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
We utilize single-cell sequencing (scSeq) of lymphocyte immune repertoires and transcriptomes to quantitatively profile the adaptive immune response in COVID-19 patients of varying age. Our scSeq analysis defines the adaptive immune repertoire and transcriptome in convalescent COVID-19 patients and ...
ORGANISM(S): Homo sapiens 
2021-03-20 | E-MTAB-10169 | biostudies-arrayexpress
ProteomicsTranscriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
ORGANISM(S): Olavius Algarvensis (ncbitaxon:188229) 
2016-02-12 | MSV000079512 | MassIVE
TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
TranscriptomicsComparison of mouse macrophages and reproductive tract epithelial cells at baseline and in an inflammatory milieu mimicking a Chlamydia genital tract infection
Chlamydia trachomatis urogenital serovars are intracellular bacteria that parasitize human reproductive tract epithelium. As the principal cell type supporting bacterial replication, epithelial cells are central to Chlamydia immunobiology initially as sentries and innate defenders, and subsequently...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-74317 | biostudies-arrayexpress
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