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MetabolomicsUltrasound Priming Enhances Seed Vigor and Multiple Stresses Tolerance in Aged Maize Seeds

Seed aging leads to reduced germination rates and vigor, particularly under stress conditions. We subjected aged maize seeds to 40 seconds of ultrasonic treatment, which enhanced their vigor and tolerance to combined stress. The ultrasonic treatment increased more cracks and holes in the seed coa...

2026-03-25 | MTBLS14138 | MetaboLights
MetabolomicsA new perspective on semen quality of aged male: The characteristics of metabolomics and proteomics

BACKGROUND: Semen quality is negatively correlated with male age and is mainly quantified by a routine semen analysis, which is descriptive and inconclusive. Sperm proteins or semen metabolites are used as the intermediate or end-products, reflecting changes in semen quality, an...

2024-01-16 | MTBLS5289 | MetaboLights
MetabolomicsUltrasound Priming Enhances Seed Vigor and Multiple Stresses Tolerance in Aged Maize Seeds
Seed vigor plays a crucial role in germination rate, population uniformity, seedling stress resistance and potential yield at maturity. Here we report a simple, eco-friendly physical method (40-second ultrasound) that rapidly triggers aged seeds to enhance seed vigor and stress resistance. Significa...
2026-07-15 | MTBLS15047 | MetaboLights
MetabolomicsPhotosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche

Aging impairs muscle regeneration, but the key constraint remains unclear. Aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH balance and redox control, forming a bioenergetic-redox bottleneck. To target this, we engineered CM-NTU-Ce, a C2C12 membrane-co...

2026-08-13 | MTBLS15312 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsMetabolomics of aged iPSC
Not available
ORGANISM(S): Mus musculus 
ST000554 | MetabolomicsWorkbench
MetabolomicsLipidomics analysis for aged mice liver (part-III)
Not available
ORGANISM(S): Mus musculus 
ST001066 | MetabolomicsWorkbench
MetabolomicsLipidomics analysis for aged mice femoral muscle (part - IV)
Not available
ORGANISM(S): Mus musculus 
ST001067 | MetabolomicsWorkbench
MetabolomicsLipidomics analysis for aged mice brain cortex (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001065 | MetabolomicsWorkbench
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
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