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TranscriptomicsTargeting the MTOR-AKT pathway in DLBCL
The mTOR (mammalian Target of Rapamycin) pathway is constitutively activated in Diffuse Large B-Cell Lymphoma (DLBCL). mTOR inhibition has been shown to have clinical activity in patients with DLBCL, although overall response rates remain low. We therefore evaluated differences in the transcriptome...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-27255 | biostudies-arrayexpress
ProteomicsNotoginsenoside R1 regulates ischemic myocardial lipid metabolism through activating AKT/mTOR signaling pathway
Radix notoginseng is widely used to treat ischemic heart disease in China and other Asian countries, and notoginsenoside R1 (NGR1) is its characteristic and large-amount ingredient. However, the potential molecular mechanisms of NGR1 improving ischemic heart diseases are unclear. Our results reveale...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD032814 | Pride
Notoginsenoside r1  ischemic heart disease  cardioprotection  lipid metabolism  akt/mtor pathway 
TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
ProteomicsTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g. PI3K/AKT/mTOR pathway) drives tumor progression. In this work, the susceptibility of the colon cancer CTC derived cell line, CTC-MCC-41, for AKT and mTOR inhibitors was evalu...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD054001 | Pride
Ctcs  pi3k/akt/mtor pathway  akt isoforms  xenotransplantation model  proteomics  mk2206  rad001  colorectal carcinoma  drug sensitivity assays  dual targeting  personalized medicine  targeted therapy 
GenomicsPI3K/AKT/mTOR Pathway and c-Myc Inhibit Hepatocyte Suspension under Simulated Microgravity
Simulated microgravity, cell suspension, PI3K/AKT/mTOR pathway, c-Myc
PRJEB96909 | ENA
GenomicsMUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway
MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway
PRJNA828438 | ENA
ProteomicsSwine Acute Diarrhea Syndrome Coronavirus Induces Autophagy to Promote Its Replication via the Akt/mTOR Pathway
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an enveloped, single‐stranded, positive‐sense RNA viruse belonging to Coronaviridae family. An increasing number of studies have demonstrated that viruses could utilize autophagy to promote their own replication. However, the relationship betwe...
ORGANISM(S): Chlorocebus sabaeus 
2023-03-11 | PXD030559 | Pride
Sars-cov autophagy itga3 
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
GenomicsCardiomyocyte S1pr1 regulates cardiac regeneration via AKT/mTOR signaling pathway
Cardiomyocyte S1pr1 regulates cardiac regeneration via AKT/mTOR signaling pathway
PRJNA1009408 | ENA
MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
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