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ProteomicsEffects of AKT inhibition in the pancreatic cancer cell proteome
The AKT pathway is a major regulator of human pancreatic adenocarcinoma progression and a key pharmacological target. The mechanisms of adaptation to long-term silencing of AKT isoforms of human and mouse pancreatic adenocarcinoma cancer cells were studied.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020673 | Pride
Pancreas Cancer Proteomics Akt Adenocarcinoma 
TranscriptomicsAKT Isoform Specificity Downstream of PIK3CA Mutation Impacts Estradiol and PI3K Inhibitor Response in Breast Cancer Cells
Background: PIK3CA mutations are observed in >30% of breast cancers, which are more common in estrogen receptor (ERα)-positive breast cancer compared with ERα-negative breast cancer. AKT1, 2, and 3 isoforms, major isoforms downstream of PI3K, modulate ERα activity. It is unknown whether PIK3CA mu...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-60759 | biostudies-arrayexpress
GenomicsProfound discrepancies between cell autonomous and systemic Akt isoform deletions have uncovered new roles for Akt isoforms in breast cancer development and metastasis
Profound discrepancies between cell autonomous and systemic Akt isoform deletions have uncovered new roles for Akt isoforms in breast cancer development and metastasis
PRJNA557427 | ENA
ProteomicsPI3Kinase Isoforms in Pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the most lethal cancers, with a 5 year-survival rate below 5%. Lack of curative treatment and failure of targeted therapies urge the need to identify novel efficient therapeutic strategy. Achievement of this goal will be obtained through the identification ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD008410 | Pride
Pi3k signaling pathway isoforms 
GenomicsmRNA-seq analysis of mouse cytotoxic T lymphocytes (CTLs) over-expressing Akt isoforms
mRNA-seq analysis of mouse cytotoxic T lymphocytes (CTLs) over-expressing Akt isoforms
PRJNA634844 | ENA
ProteomicsTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g. PI3K/AKT/mTOR pathway) drives tumor progression. In this work, the susceptibility of the colon cancer CTC derived cell line, CTC-MCC-41, for AKT and mTOR inhibitors was evalu...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD054001 | Pride
Ctcs  pi3k/akt/mtor pathway  akt isoforms  xenotransplantation model  proteomics  mk2206  rad001  colorectal carcinoma  drug sensitivity assays  dual targeting  personalized medicine  targeted therapy 
UnknownPHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.
Not available
S-EPMC9664818 | biostudies-literature
UnknownOpposing functions of Akt isoforms in lung tumor initiation and progression.
Not available
S-EPMC3983215 | biostudies-literature
UnknownAkt isoforms differentially provide for chemoresistance in prostate cancer.
Not available
S-EPMC9196054 | biostudies-literature
UnknownAKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.
Not available
S-EPMC5722612 | biostudies-literature
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