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UnknownLeveraging genetic data to investigate molecular targets and drug repurposing candidates for treating alcohol use disorder and hepatotoxicity.
Not available
S-EPMC7423741 | biostudies-literature
ProteomicsEffects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver
In this study, to better understand the mechanisms of the profound impact of alcohol consumption on drug pharmacokinetics, efficacy, and toxicity, we characterized the alcohol-induced changes in the ensemble of drug-metabolizing enzymes and transporters (DMETs) in the human liver by performing globa...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD060653 | Pride
Drug metabolism  human liver microsomes  cytochromes p450  alcohol consumption  tobacco smoking  proteomics  alcohol–drug interactions 
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
UnknownDrug-Alcohol Interactions in Older U.S. Adults.
Not available
S-EPMC4674266 | biostudies-literature
UnknownOxytocin for the treatment of drug and alcohol use disorders.
Not available
S-EPMC5089904 | biostudies-literature
TranscriptomicsComparative genomic hybridization by array of east haploid and heterozygous essential deletion pools treated with compounds synergistic with fluconazole to identify sensitive and resistant mutants
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-07 | E-MTAB-394 | biostudies-arrayexpress
UnknownGender, employment, and continuous pandemic as predictors of alcohol and drug consumption during the COVID-19.
Not available
S-EPMC8411591 | biostudies-literature
UnknownDrinking cultures and socioeconomic risk factors for alcohol and drug use disorders among first- and second-generation immigrants: A longitudinal analysis of Swedish population data.
Not available
S-EPMC8355220 | biostudies-literature
ProteomicsFunctional effects of CYP3A-CYP2E1 interactions and their role in activation of CYP3A enzymes by chronic alcohol exposure
Aiming to examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of two CYP3A-specific substrates, 7-benzyloxyquinoline (7-BQ) and ivermectin, in 23 preparations of human liver microsomes (HLM) obtained from donors with documented al...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD079247 | Pride
Cytochrome p450  cyp2e1  cyp3a4  cyp3a5  nadph-cytochrome p450 reductase  pro-tein-protein interactions  7-benzyloxyquinoline  ivermectin  human liver microsomes  alcohol consumption  alcohol-drug interactions  cross-linking mass spectrometry 
UnknownDrug interactions in patients with alcohol use disorder: results from a real-world study on an addiction-specific ward.
Not available
S-EPMC11742168 | biostudies-literature
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