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ProteomicsA non-coding role for trypanosome VSG transcripts in allelic exclusion
Bloodstream-form African trypanosomes display mono-telomeric expression of a Variant Surface Glycoprotein (VSG) gene in an inter-chromosomally bridged transcription and splicing compartment, such that the dominant gene produces 10,000 times more transcript than excluded VSG genes. Antigenic variatio...
ORGANISM(S): Trypanosoma brucei 
2025-03-11 | PXD060524 | Pride
Antigenic variation Trypanosoma brucei. Cncrna Monoallelic 
TranscriptomicsAllele specific analysis of the immunoglobulin heavy chain locus by simultaneous analysis of the productive and the non-productive allele through paired-end 4C sequencing analysis in mature B cells
In developing B cells the immunoglobulin heavy chain (IgH) locus is thought to move from repressive to permissive chromatin compartments to facilitate its scheduled rearrangement. In mature B cells, maintenance of allelic exclusion has been proposed to involve recruitment of the non-productive IgH a...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-47128 | biostudies-arrayexpress
TranscriptomicsExpression data for resting and activated B and T cells
The IgH locus encodes for part of the antibody exposed by B cells and is important for the immune system. In B cells, one allele produces protein, the other must remain silenced. It was proposed that both alleles reside in different nuclear compartments and that this is important to maintain mono-al...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-46865 | biostudies-arrayexpress
UnknownGermline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.
Not available
S-EPMC1864970 | biostudies-literature
TranscriptomicsThe developmental dynamics and disease potential of random monoallelic gene expression
X-chromosome inactivation (XCI) in females and allelic exclusion of olfactory receptor or immunoglobulin loci, represent classic examples of random monoallelic expression (RME). RME of some single copy genes has also been reported, but the in vivo relevance of this remains unclear. Here we identify ...
ORGANISM(S): Mus musculus 
2014-02-27 | E-GEOD-54016 | biostudies-arrayexpress
UnknownA non-coding role for trypanosome VSG transcripts in allelic exclusion.
Not available
S-EPMC12539627 | biostudies-literature
UnknownVEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.
Not available
S-EPMC4932947 | biostudies-literature
UnknownA role for the IgH intronic enhancer E mu in enforcing allelic exclusion.
Not available
S-EPMC2626684 | biostudies-literature
UnknownIncomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.
Not available
S-EPMC3594800 | biostudies-literature
UnknownPoor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion.
Not available
S-EPMC7478721 | biostudies-literature
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