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GenomicsNMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
NMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
PRJNA578282 | ENA
GenomicsREPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
PRJNA756978 | ENA
ProteomicsAn SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, combining ATP-site and allosteric kinase inhibitors can overc...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054878 | Pride
Hck  hdx-ms  hydrogen/deuterium exchange mass spectrometry  allosteric modulator  global conformation 
TranscriptomicsNMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
To investigate genome-wide gene expression changes induced by an NMDA receptor positive allosteric modulator in neuronal cultures using next-generation sequencing
ORGANISM(S): Rattus norvegicus 
2021-01-01 | GSE139080 | GEO
GenomicsDiscovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
PRJNA559935 | ENA
TranscriptomicsREPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their dysregulation associated with human disease including cancer, CB...
ORGANISM(S): Homo sapiens 
2022-01-03 | GSE182592 | GEO
UnknownUnderstanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator.
Not available
S-EPMC9818451 | biostudies-literature
UnknownMolecular Modeling Study of a Receptor-Orthosteric Ligand-Allosteric Modulator Signaling Complex.
Not available
S-EPMC10032570 | biostudies-literature
UnknownAlloFinder: a strategy for allosteric modulator discovery and allosterome analyses.
Not available
S-EPMC6030990 | biostudies-literature
UnknownDiscovery of a Negative Allosteric Modulator of GABAB Receptors.
Not available
S-EPMC4094264 | biostudies-literature
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