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ProteomicsCASK phosphorylation pattern in the presence of constitutively active HCK
The SRC inhibitor PP2 can block CASK nucleus translocation in macrophage under H5N1 infection. Since PP2 is a general inhibitor for Src family kinases (SFKs), which includes nine members (Csk, Yes, Fyn, Fgr, Lck, Hck, Blk, Lyn, and Frk), we aimed to identify the specific member responsible for the n...
ORGANISM(S): Homo sapiens (Human) 
2025-01-09 | PXD057889 | Pride
Cask Phosphorylation Hck 
ProteomicsAn SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, combining ATP-site and allosteric kinase inhibitors can overc...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054878 | Pride
Hck  hdx-ms  hydrogen/deuterium exchange mass spectrometry  allosteric modulator  global conformation 
GenomicsInhibition of the SRC-kinase HCK restricts pancreatic cancer development and metastasis
Inhibition of the SRC-kinase HCK restricts pancreatic cancer development and metastasis
PRJNA769579 | ENA
TranscriptomicsInhibition of the SRC-kinase HCK restricts pancreatic cancer development and metastasis
Pancreatic cancer is an aggressive disease with a low 5-year survival rate and poor response to therapy. Here, we demonstrate that inhibition of the myeloid-specific SRC family-kinase HCK impairs pancreatic tumor growth and metastasis by enhancing the infiltration of cytotoxic effector cells, stimul...
ORGANISM(S): Mus musculus 
2022-10-11 | GSE185540 | GEO
GenomicsRASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
RASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
PRJNA1380299 | ENA
GenomicsBacteroides uniformis strain:FSDTA-HCK-B1
Bacteroides uniformis strain:FSDTA-HCK-B1 Genome sequencing and assembly
PRJNA609870 | ENA
GenomicsBacteroides ovatus strain:FSDTA-HCK-B4
Bacteroides ovatus strain:FSDTA-HCK-B4 Genome sequencing and assembly
PRJNA609877 | ENA
GenomicsBacteroides fragilis strain:FSDTA-HCK-B8
Bacteroides fragilis strain:FSDTA-HCK-B8 Genome sequencing and assembly
PRJNA609849 | ENA
UnknownHCK regulates NLRP12-mediated PANoptosis.
Not available
S-EPMC12130821 | biostudies-literature
UnknownHCK promotes glioblastoma progression by TGFβ signaling.
Not available
S-EPMC7300285 | biostudies-literature
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