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ProteomicsCASK phosphorylation pattern in the presence of constitutively active HCK
The SRC inhibitor PP2 can block CASK nucleus translocation in macrophage under H5N1 infection. Since PP2 is a general inhibitor for Src family kinases (SFKs), which includes nine members (Csk, Yes, Fyn, Fgr, Lck, Hck, Blk, Lyn, and Frk), we aimed to identify the specific member responsible for the n...
ORGANISM(S): Homo sapiens (Human) 
2025-01-09 | PXD057889 | Pride
Cask Phosphorylation Hck 
ProteomicsIdentification of CASK nuclear interactome in resting and H5N1-activated GM-macrophage by IP-LC-MS/MS
We investigated how nuclear CASK regulates the export of Ifna mRNA to the cytosol. As CASK is a scaffold protein known to interact with many proteins via its PDZ, L27, SH3, and GK domain, we explored whether CASK interacts with nuclear proteins involved in the export of messenger ribonucleoprotein (...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-09 | PXD058016 | Pride
Macrophage Cask H5n1 influenza virus Nuclear interactome 
GenomicsPresynaptic dysfunction in CASK-related neurodevelopmental disorders
Presynaptic dysfunction in CASK-related neurodevelopmental disorders
PRJNA590196 | ENA
GenomicsCASK mutation Disrupts Neural Connectivity in Human Neurons
CASK mutation Disrupts Neural Connectivity in Human Neurons
PRJNA821972 | ENA
UnknownThe neurodevelopmental spectrum of CASK-related disorder.
Not available
S-EPMC12492526 | biostudies-literature
TranscriptomicsPresynaptic dysfunction in CASK-related neurodevelopmental disorders
CASK-related disorders are a growing group of genetic neurodevelopmental syndromes. There is limited information about the effects of CASK mutations in human neurons. Therefore, we sought to delineate CASK mutation consequences and neuronal level effects using induced pluripotent stem cell-derived n...
ORGANISM(S): Homo sapiens 
2020-07-27 | GSE140572 | GEO
UnknownPatient-Derived Variants Define Constraints for Ligand Binding at the PDZ Domain of CASK.
Not available
S-EPMC12666738 | biostudies-literature
TranscriptomicsCASK mutation Disrupts Neural Connectivity in Human Neurons 
Loss-of-function mutations in CASK cause severe developmental phenotypes including microcephaly with pontine and cerebellar hypoplasia (MICPHC), X-linked intellectual disability and autism. Modeling of CASK-related disorders has been challenging due to limited human cellular models to study the mult...
ORGANISM(S): Homo sapiens 
2022-04-03 | GSE199910 | GEO
UnknownTwo microcephaly-associated novel missense mutations in CASK specifically disrupt the CASK-neurexin interaction.
Not available
S-EPMC6391276 | biostudies-literature
UnknownPresynaptic dysfunction in CASK-related neurodevelopmental disorders.
Not available
S-EPMC7490425 | biostudies-literature
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