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UnknownEosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis.
Not available
S-EPMC12541001 | biostudies-literature
ProteomicsIFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we used ALS6 patient-derived induced pluripotent stem ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038042 | Pride
Als  als6  fus  protein synthesis  ifny 
GenomicsHITS-CLIP analysis of FUS in lineage-committed cells.
In the present study, we performed HITS-CLIP analysis for FUS using mouse brain to extensively characterize tits RNA-binding sites and functional roles in RNA metabolisms. We identified preferential binding of FUS to stem-and-loop structures but without any discernible consensus motifs. FUS was pref...
ORGANISM(S): Mus musculus 
2012-07-26 | E-GEOD-37190 | biostudies-arrayexpress
TranscriptomicsFUS KO mRNA sequencing and anti-FUS RNA immunoprecipitation sequencing
The aim of our study is to identify the role of FUS in shaping the transcriptome. RNA-seq of two FUS KO clones was performed and compared to wt; for each, four replicates were sequenced. RNA molecules associated with the FUS protein were determined by means of a RNA immuno-precipitation, followed by...
ORGANISM(S): Homo sapiens 
2016-06-13 | E-GEOD-71812 | biostudies-arrayexpress
TranscriptomicsIdentification of FUS RNA targets in HeLa cells
We identified a landscape of FUS-binding RNA targets in HeLa cells. The majority of the FUS binding sites are in introns of pre-mRNAs and less are in exons and untranslated regions. Significant FUS binding in introns flanking cassette exons, long intron (>100kb) containing transcripts and noncoding...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50178 | biostudies-arrayexpress
TranscriptomicsIdentification of in vivo, conserved, FUS RNA binding sites and the impact of FUS on the neuronal transcriptome
FUS, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of FUS and the assessment of the impact of FUS depletion on the neuronal transcriptome. We identif...
ORGANISM(S): Homo sapiens 
2013-01-25 | E-GEOD-43308 | biostudies-arrayexpress
TranscriptomicsToxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS. Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of ...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-78730 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Fus
To clarify the functional properties of FUS, we established the differentially expressed alternative exons in FUS-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary cortical neuron infected with lentivirus expressing shRNA against mouse ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-36153 | biostudies-arrayexpress
UnknownMutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Not available
S-EPMC4516382 | biostudies-literature
TranscriptomicsTLS ChIP-chip
ChIP using anti-TLS antibody and control to examine binding sites.
ORGANISM(S): Homo sapiens 
2012-03-15 | E-MEXP-3568 | biostudies-arrayexpress
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