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ProteomicsAcetylome analysis of acetylation providing new insight into sclerotial generation in medicinal fungus Polyporus umbellatus
Polyporus umbellatus sclerotia are medicinal tissue, but little is known about acetylome of sclerotia generated from hyphae. Acetylated peptides in P. umbellatus were enriched by anti-acetyl-lysine antibody beaded agarose and DDA data were acquired by AB Triple TOF 5600+. Raw data were analyzed by P...
ORGANISM(S): Polyporus umbellatus GSX09 
2022-05-20 | PXD031195 | Pride
Ab triple tof5600+ Polyporus umbellatus 
ProteomicsKansl2 dependent acetylome study in primary Kansl2 (fl/fl) murine embryonic fibroblasts
As one of the most important post-translational protein modifications, lysine acetylation is catalyzed by lysine acetyltransferases (KATs), which catalyze the covalent attachment of an acetyl group to the N epsilon–residue of lysine. The histone acetyltransferase MOF, which represents the main histo...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-05 | PXD038521 | Pride
Kat8 regulatory nsl complex subunit 2  mef (murine embryonic fibroblast)  primary inducible kansl2 knock-out  cre-ert2  anti acetyl-lysine antibody  ptm enrichment 
TranscriptomicsChIP-chip by array of mouse cell lines and fresh tissue using anti-acetyl histone H3 antibody.
Immunoprecipitations were performed using anti-acetyl histone H3 antibody (Millipore, 06-599)
ORGANISM(S): Mus musculus 
2011-04-07 | E-MEXP-2664 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of mouse haematopoietic and endothelial cell lines using an anti-H3 trimethyl lysine 4 antibody
chromatin immunoprecipitations were performed in mouse haematopoietic and endothelial cell lines using an anti-H3 trimethyl lysine 4 antibody
ORGANISM(S): Mus musculus 
2011-09-06 | E-MEXP-2908 | biostudies-arrayexpress
ProteomicsHFD mice liver acetylome characterization
Obesity is often linked to protein acetylation and induces intricate changes in post-translational modifications, affecting mitochondrial regulatory instability. Redox signaling is crucial for maintaining cellular homeostasis. The mechanism by which lysine acetylome drives redox signaling may elucid...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD071476 | Pride
Post-translational modification Liver Lc-ms/ms 
ProteomicsCharacterization of lysine acetylation in Toxoplasma gondii proteome lacking acetyl-CoA transporter 1 (AT1).
Acetyl-CoA participates in post-translational modification of proteins, central carbon and lipid metabolism in several cell compartments. In mammals, the acetyl-CoA transporter 1 (AT1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER), enabling the acetylation of prote...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-07-25 | PXD030932 | Pride
Lysine acetylation Toxoplasma gondii Acetyl-coa transporter 1 Nanolc-ms/ms 
ProteomicsDeep, quantitative coverage of the lysine acetylome using novel anti-acetyl-lysine antibodies
Svinkina T, Gu H, Silva JC, Mertins P, Qiao J, Fereshetian S, Jaffe JD, Kuhn E, Udeshi ND,Carr SA. Mol Cell Proteomics, 2015. Introduction of antibodies specific for acetylated lysine has significantly improved the detection of endogenous acetylation sites by mass spectrometry. Here, we describe a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2015-03-08 | MSV000079068 | MassIVE
UnknownDeep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow.
Not available
S-EPMC4563726 | biostudies-literature
ProteomicsMalonylation of Acetyl-CoA Carboxylase 1 Promotes Hepatic Steatosis and Is Attenuated by Ketogenic Diet in NAFLD
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the involvement of PTMs in ketogenic diet (KD)-improved fatty liver by multi-om...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD040481 | Pride
Lysine malonylation  hepatic steatosis  acetyl-coa carboxylase 1  ketogenic diet. 
ProteomicsAcetyl-proteome profiling of Staphylococcus aureus revealed lysine acetylation in bacterial antibiotic resistance
Protein post-translational modifications (PTMs) play crucial roles in various biological processes across prokaryotes and eukaryotes. Lysine acetylation (Kac), which is observed in different bacteria species and is known to be a dynamic and reversible PTM involved in numerous physiological functions...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD043277 | Pride
Post-translational modification  staphylococcus aureus  antibiotic resistance  lysine acetylation  ribosome 
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