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Background: Methicillin-resistant Staphylococcus aureus (MRSA) biofilms exhibit high levels of drug resistance and cause nosocomial infections in humans, thus posing a sustainable global health threat. This underscores the critical need to develop novel antibiofilm therapeutics with high efficacy...

2025-09-18 | MTBLS13012 | MetaboLights

The global proliferation of methicillin-resistant Staphylococcus aureus (MRSA) persists as a significant contributor to challenging infections, highlighting the urgent necessity for therapies that utilize novel mechanisms. Aspartate transcarbamoylase (ATCase), which catalyzes the initial committe...

2026-01-14 | MTBLS13673 | MetaboLights
Brevibacillus sp. SPR20 produced potentially antibacterial substances against MRSA. The synthe-sis of these substances is controlled by their biosynthetic gene clusters. Several mutagenesis methods are used to overcome the restriction of gene regulations when genetic information is ab-sent. Atmosphe...
ORGANISM(S): Brevibacillus sp. 
2023-08-31 | PXD043954 | Pride
S aureus was treated in triplicate with 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside (KCR), oxacillin or vehicle and quantitative proteomic analysis was carried out using isobaric tags and mass spectrometry. 1190 proteins were identified and 552 were affected by KCR (q<0.01). Ontology analysis ide...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
Hemolysins are lytic exotoxins expressed in most strains of S. aureus, but hemolytic activity varies between strains. We have previously reported several novel anti-virulence compounds that disrupt the S. aureus transcriptome, including hemolysin gene expression. This report delves further into our ...
ORGANISM(S): Staphylococcus aureus 
2024-05-15 | GSE267020 | GEO
Novel anti-virulence compounds disrupt exotoxin expression in MRSA
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