The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
Mycobacterium bovis, the causative agent of bovine tuberculosis, poses a significant zoonotic threat. This study defines the antibacterial activity and mechanism of the natural alkaloid isocorydine (ICD) against M. bovis using an integrated multi-omics approach. Phenotypic analyses demonstrated t...
The rising threat of antimicrobial resistance necessitates sustainable alternatives to synthetic antibiotics, driving interest in plant-derived compounds for livestock feed. Cyperus esculentus L. (tiger nut) exhibits promising antibacterial properties, yet gaps persist in understanding its specific ...
Prediction of antimicrobial potential using a dataset of 29537 compounds screened against the antibiotic resistant pathogen Burkholderia cenocepacia. The model uses the Chemprop Direct Message Passing Neural Network (D-MPNN) and has an AUC score of 0.823 for the test set. It has been used to virtual...
