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MetabolomicsMetabolomics Characterization of Human Calcific Aortic Valve Stenosis

BACKGROUND: Calcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease in developed countries with significant morbidity and mortality. Given the poor understanding of the pathophysiological processes leading to CAVS, we utilized a joint non-targeted metab...

2020-02-03 | MTBLS1267 | MetaboLights
MetabolomicsValvular lipidomic changes in progression of human calcific aortic valve stenosis
This study investigates lipid dysregulation in calcific aortic valve stenosis (CAVS) by analyzing lipid profiles in valve tissues from 99 patients across different disease severities (mild, moderate, severe) using liquid chromatography-mass spectrometry (LC-MS). The results reveal distinct lipid alt...
2025-01-28 | MTBLS11713 | MetaboLights
TranscriptomicsmRNA profiling in aortic stenosis
We compared mRNA profiles of 10 participants with severe aortic stenosis undergoing aortic valve replacement to 10 samples donated post-mortem.
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-3105 | biostudies-arrayexpress
TranscriptomicsGene expression profile of normal and calcified stenotic human aortic valves
We explored gene expression profile of human aortic valves in patients with or without aortic stenosis. The dataset that we generated constitutes a large-scale quantitative measurements of gene expression in normal and stenotic human valves. The goal was to compare gene expression levels between the...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-12644 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling in aortic stenosis
We compared 15 severely diseased aortic valve sample to 16 control aortic valve samples using microRNA microarrays (Affymetrix GeneChip miRNA 2.0). The diseased samples were taken from areas of severe disease of aortic valves removed at aortic valve replacement for severe aortic stenosis. Control sa...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-2766 | biostudies-arrayexpress
ProteomicsPericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling
Patients with aortic stenosis are often indicated to aortic valve replacement to relief pressure overload. After surgery, patients experience a myocardial response commonly known as reverse remodeling, where structural and functional recovery are expected. Notwithstanding, some patients exhibit an i...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD015607 | Pride
Human Coronary artery disease Aortic stenosis Pericardial fluid Reverse remodeling 
GenomicsTargeted sequencing of candidate genes in calcific aortic valve stenosis
The objective is to identify new disease genes involved in calcific aortic valve stenosis (CAVS) by screening newly identified candidate genes. The recruitment of patients with CAVS has been achieved by l’institut du thorax (Nantes, France). DNA from the selected patients has been analysed by target...
EGAS00001000308 | EGA
TranscriptomicsCirculating microRNA profile in aortic stenosis
We compared the circulating plasma microRNA profile in EDTA plasma in patients with aortic stenosis to a control group.
ORGANISM(S): Homo sapiens 
2015-08-25 | E-MTAB-2785 | biostudies-arrayexpress
GenomicsExome sequencing in patients with Calcific Aortic Valve Stenosis
The objective is to identify new genes involved in calcific aortic valve stenosis (CAVS) by screening the exome of at least 20 patients with familial CAVS. The recruitment of patients with CAVS has been achieved by l’institut du thorax (Nantes, France). DNA from the selected patients has been analys...
EGAS00001000049 | EGA
TranscriptomicsTranscription profiling of human heart characterizing the progression of heart failure in patients with aortic valve stenosis
Myocardial left ventricular biopsies from male patients (n=6) with isolated aortic stenosis and pronounced left ventricular hypertrophy undergoing aortic valve replacement were harvested either from hearts with normal ejection fraction (EF,>50%) or with low EF (<30%). Biopsies were further obtained ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-MEXP-2296 | biostudies-arrayexpress
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